Evidence map›Paper›PMID 42729694›Full record

ReviewCancer drug resistance (Alhambra, Calif.)2026

Adenylosuccinate lyase in pancreatic ductal adenocarcinoma chemoresistance: from purine metabolism to metabolic vulnerability.

Tung-Wei Hsu, Chih-Ming Su, Yen-Hao Su, Po-Hsiang Liao, Charupong Saengboonmee, Wan-Yu Wang, Hsin-An Chen

Abstract readReview
In one paragraph

Review in Cancer drug resistance (Alhambra, Calif.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Tung-Wei HsuDepartment of Surgery, Division of General Surgery, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan.
Chih-Ming SuDepartment of Surgery, Division of General Surgery, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan.
Yen-Hao SuDepartment of Surgery, Division of General Surgery, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan.
Po-Hsiang LiaoCenter for Drug Research and Development, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 333324, Taiwan.
Charupong SaengboonmeeDepartment of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand.
Wan-Yu WangDepartment of Surgery, Division of General Surgery, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan.
Hsin-An ChenDepartment of Surgery, Division of General Surgery, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is among the most lethal human malignancies and is characterized by profound metabolic reprogramming and marked therapeutic resistance. Among the metabolic enzymes that sustain tumor fitness, adenylosuccinate lyase (ADSL) has emerged as a critical regulator of

Indexed as

Adenylosuccinate lyasechemoresistancemetabolic reprogrammingpancreatic ductal adenocarcinomapurine metabolismtherapeutic targeting

Identifiers

PMID42729694
PMCPMC13563462

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.