Evidence map›Paper›PMID 42729643›Full record

ReviewFrontiers in microbiology2026

Clinical translation of salivary MicroAge for understanding the oral-systemic connection in healthy longevity.

Tongjun Guo, Yixuan Chen, Yuehan Yu, Yilin Shao, Cong Wang, Xue Li, Haoyu Zhang, Chao Xu, Yoo Cheung, Feng Chen and 3 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Tongjun GuoFifth Clinical Division, National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, School and Hospital of Stomatology, Peking University, Beijing, China.
Yixuan ChenFifth Clinical Division, National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, School and Hospital of Stomatology, Peking University, Beijing, China.
Yuehan YuFifth Clinical Division, National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, School and Hospital of Stomatology, Peking University, Beijing, China.
Yilin ShaoFifth Clinical Division, National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, School and Hospital of Stomatology, Peking University, Beijing, China.
Cong WangFifth Clinical Division, National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, School and Hospital of Stomatology, Peking University, Beijing, China.
Xue LiFifth Clinical Division, National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, School and Hospital of Stomatology, Peking University, Beijing, China.
Haoyu ZhangFifth Clinical Division, National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, School and Hospital of Stomatology, Peking University, Beijing, China.
Chao XuFifth Clinical Division, National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, School and Hospital of Stomatology, Peking University, Beijing, China.
Yoo CheungLingchuan Stomatology Inc., Beijing, China.
Feng ChenCentral Laboratory, National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, School and Hospital of Stomatology, Peking University, Beijing, China.
Tiansong XuFifth Clinical Division, National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, School and Hospital of Stomatology, Peking University, Beijing, China.
Xiuhua LiFifth Clinical Division, National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, School and Hospital of Stomatology, Peking University, Beijing, China.
Chenggang DuanFifth Clinical Division, National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, School and Hospital of Stomatology, Peking University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The oral-systemic connection, salivary microbiome, and healthy longevity are increasingly recognized as biologically interconnected. This review summarizes lifespan changes in the salivary microbiome, its links to age-related systemic diseases, and recent progress in salivary MicroAge modeling. It further highlights advances in data preprocessing, feature engineering, and artificial intelligence-based prediction, while emphasizing the importance of standardization, generalizability, and biological interpretability for clinical translation. Overall, salivary MicroAge may provide a noninvasive and interpretable framework for biological aging assessment and healthier aging.

Indexed as

biological agingclinical translationmodel interpretabilityoral microbiomepredictive modelingsalivary MicroAge

Identifiers

PMID42729643
PMCPMC13563518

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.