ArticleCellular and molecular bioengineering2026
Sex Differences in Angiogenic Ligand and Receptor Protein Expression During Adipose Tissue Expansion and Regression.
Article in Cellular and molecular bioengineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Review
- Obesity Alters the Vascular Morphology and VEGF-A Signaling in Adipose Tissue.FASEB bioAdvances · 2025Article
- The Advanced Glycation End-Products (AGE)-Receptor for AGE System (RAGE): An Inflammatory Pathway Linking Obesity and Cardiovascular Diseases.International journal of molecular sciences · 2025Review
Corrections and comments
- Update of
Authors and funding
4 authors.
Funding
Abstract
Purpose: Inadequate angiogenesis in obesogenic adipose tissue (AT) has been implicated in disrupted adipogenesis and metabolic disorders. While several regulators of AT angiogenesis have been identified, our understanding of the quantitative changes in angiogenic signaling proteins during obesity progression remains incomplete, particularly regarding sex-specifi c responses. This study sought to identify the dysregulated elements within the Vascular Endothelial Growth Factor (VEGF) and Platelet-Derived Growth Factor (PDGF) systems during obesity progression. Methods: We employ a mouse model, comprising both male and female mice, to investigate the changes in the VEGF/PDGF concentration and their receptor distribution in gonadal AT during short- and long-term weight gain and weight loss. Results: Female mice preserve adipose tissue angiogenic signatures during obesity progression, including sustained upregulation of endothelial VEGFR1 protein, maintenance of VEGF-A levels and endothelial cell populations, and differential regulation of PDGF levels, compared to males. These sex-specifi c patterns correlate with improved adipose expandability and may contribute to the more metabolically healthy obesity phenotype commonly observedin females. Conclusion: These sex-specifi c patterns correlate with improved adipose expandability and may contribute to the more metabolically healthy obesity phenotype commonly observed in females. Our quantitative profi ling also lays the groundwork for developing computational models of VEGF/PDGF signaling networks in AT, allowing for the simulation of complex biological interactions and the prediction of therapeutic outcomes. Supplementary Information: The online version contains supplementary material available at https://doi.org/10.1007/s12195-026-00925-x.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.