Evidence map›Paper›PMID 42729578›Full record

ArticleJournal of tropical medicine2026

Antiplasmodial Activity of Methylangolensate From

Jude Tetteh, Jemima Aggrey Appiah, Felix Zoiku, Derwaa Keteku, Bismark Aboagye-Adjei, Arnold Donkor Forkuo, Isaac Kingsley Amponsah, Charles Ansah, Kwesi Boadu Mensah

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of tropical medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jude TettehDepartment of Pharmacology, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana, knust.edu.gh.ORCID https://orcid.org/0009-0001-7251-7821
Jemima Aggrey AppiahDepartment of Pharmaceutical Science, Kumasi Technical University, Kumasi, Ghana, kstu.edu.gh.ORCID https://orcid.org/0009-0008-3526-5152
Felix ZoikuNoguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana, ug.edu.gh.ORCID https://orcid.org/0000-0002-3252-0575
Derwaa KetekuDepartment of Pharmacology, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana, knust.edu.gh.ORCID https://orcid.org/0009-0009-2738-3228
Bismark Aboagye-AdjeiDepartment of Pharmacology, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana, knust.edu.gh.ORCID https://orcid.org/0009-0000-8386-6819
Arnold Donkor ForkuoDepartment of Pharmacology, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana, knust.edu.gh.ORCID https://orcid.org/0000-0003-0548-2400
Isaac Kingsley AmponsahDepartment of Pharmacology, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana, knust.edu.gh.ORCID https://orcid.org/0000-0001-5587-1071
Charles AnsahDepartment of Pharmacology, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana, knust.edu.gh.ORCID https://orcid.org/0000-0001-6044-6117
Kwesi Boadu MensahDepartment of Pharmacology, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana, knust.edu.gh.ORCID https://orcid.org/0000-0002-9649-2497

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Previous investigation of the antiplasmodial effects of methylangolensate (MAL) has revealed promising activity against multiple strains of Methods: The cytotoxic effects of MAL on HepG2 cells and the inhibitory effects of MAL against the blood stages of both 3D7 Results: MAL demonstrated minimal cytotoxic effects (CC Conclusion: MAL may serve as a lead compound for the design and development of novel drugs that elicit their antiplasmodial effects by interfering with folate metabolism, DNA synthesis, energy metabolism, and nutrition of the

Indexed as

drug likenessmethylangolensatemolecular dockingmolecular dynamic simulationsmultistage

Identifiers

PMID42729578
PMCPMC13563057

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.