Evidence map›Paper›PMID 42729546›Full record

ReviewFrontiers in oral health2026

Preliminary evidence of effectiveness of preparations from

Sigrun Chrubasik-Hausmann, Julia Vlachojannis, Marietta Wolf, Fabian Cieplik, Ali Al-Ahmad

Abstract readReview
In one paragraph

Review in Frontiers in oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sigrun Chrubasik-HausmannFaculty of Medicine, Institute of Forensic Medicine, University of Freiburg, Freiburg, Germany.
Julia VlachojannisFaculty of Medicine, Institute of Forensic Medicine, University of Freiburg, Freiburg, Germany.
Marietta WolfDepartment of Operative Dentistry and Periodontology, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.
Fabian CieplikDepartment of Operative Dentistry and Periodontology, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.
Ali Al-AhmadDepartment of Operative Dentistry and Periodontology, Faculty of Medicine, Medical Center - University of Freiburg, Freiburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Preparations of Objective: To critically evaluate the current clinical evidence regarding the use of Methods: A systematic literature search following PRISMA guidelines was conducted in PubMed, Embase, Scopus, Web of Science, and Cochrane CENTRAL for English-language clinical studies published through July 2026. Eligible studies investigated preparations of Results: Fourteen exploratory clinical trials were identified. Overall, adjunctive use of Discussion: Without knowledge of the administered TQ dose, neither dose-response relationships nor reliable sample-size calculations for confirmatory trials can be established. Experimental evidence nevertheless supports the biological plausibility of the observed clinical findings and provides a rationale for further clinical investigation. Conclusions: Current clinical evidence remains preliminary and hypothesis-generating despite encouraging findings. Future confirmatory randomized controlled trials should employ well-characterized, TQ-standardized preparations and report the administered TQ dose to enable reproducibility, dose-response assessment, and evidence-based study planning.

Indexed as

adjunctive therapyblack seedevidence of effectivenessgingivitisNigella sativaoral diseasesperi-implantitisperiodontitis

Identifiers

PMID42729546
PMCPMC13563123

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.