ReviewOncology letters2026
Inhibition or induction of gastrointestinal tumors by ferroptosis and intervention by herbal extracts (Review).
Review in Oncology letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ferroptosis is a regulated form of iron-dependent cell death characterized by lipid peroxidation and oxidative stress. Increasing evidence indicates that ferroptosis plays an important role in gastrointestinal (GI) tumors, including esophageal, gastric, hepatic and colorectal cancer. Depending on the cellular context, ferroptosis may suppress tumor growth or contribute to therapy resistance. The present review summarizes the molecular mechanisms underlying ferroptosis in GI cancer, with a focus on iron metabolism, lipid peroxidation and the solute carrier family 7 member 11-reduced glutathione-glutathione peroxidase 4 axis antioxidant system. Common regulatory patterns and tumor-specific characteristics are discussed. In addition, the potential of herbal extracts to induce ferroptosis in GI tumors is reviewed, and current limitations in clinical translation are addressed. Clarifying the regulatory determinants of ferroptosis may improve therapeutic stratification in GI cancer.
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