ArticleFrontiers in cardiovascular medicine2026
Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
11 authors.
Funding
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Abstract
Objective: Bacterial DNA from oral microorganisms has been found in various cardiovascular tissues, including abdominal aortic aneurysm (AAA) tissue. In addition, experiments in murine models have shown that the oral pathogen Methods: A total of 73 oral wash samples were collected from 45 subjects with AAA and 28 with atherosclerotic disease. Bacterial DNA was isolated, and the V1-V3 segment of the bacterial 16S rRNA gene was amplified. Taxonomic profiles were constructed using DADA2, and statistical inferences on alpha diversity, beta diversity, and differential abundance were performed, adjusting for age, sex, smoking status, and cancer history. Sensitivity analyses additionally adjusted for cancer status, statin use, proton pump inhibitor use, and diabetes. Bacterial gene potential functions were predicted using PICRUSt2. Results: The oral microbial community composition differed in beta diversity (weighted UniFrac distance, Conclusions: These findings demonstrate that the oral microbiome differs between patients with AAA and those with advanced atherosclerotic disease and support further investigation of oral microbial alterations and their relationship to vascular pathologies. The known link between
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