Evidence map›Paper›PMID 42729417›Full record

ArticleFrontiers in nutrition2026

Whole wheat bread improves postprandial glucose tolerance in adults with prediabetes: a controlled-feeding randomized crossover trial with microbiome-associated variation in response.

Jillian T Pierson, Ariana H Bond, Sisi Cao, Shiqi Zhang, Andrew Gold, Huan Zhang, Kaitlyn M Zamary, Ayse Gurer, Chao Guo, Menuka Bhandari and 5 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05318183 (Assessing Gut Microbiota Mediated Health Outcomes of Whole Wheat and Its Major Bioactive Components), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05318183 naactive not recruitingnot on this map

Assessing Gut Microbiota Mediated Health Outcomes of Whole Wheat and Its Major Bioactive Components

TypeinterventionalSponsorOhio State UniversityRan2022 to 2026Enrolled65ConditionsPreDiabetes, Dysbiosis, Endotoxemia, InflammationArmsWhole Wheat Bread, White Bread (control)
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jillian T PiersonHuman Nutrition Program, The Ohio State University, Columbus, OH, United States.
Ariana H BondHuman Nutrition Program, The Ohio State University, Columbus, OH, United States.
Sisi CaoHuman Nutrition Program, The Ohio State University, Columbus, OH, United States.
Shiqi ZhangHuman Nutrition Program, The Ohio State University, Columbus, OH, United States.
Andrew GoldHuman Nutrition Program, The Ohio State University, Columbus, OH, United States.
Huan ZhangHuman Nutrition Program, The Ohio State University, Columbus, OH, United States.
Kaitlyn M ZamaryHuman Nutrition Program, The Ohio State University, Columbus, OH, United States.
Ayse GurerHuman Nutrition Program, The Ohio State University, Columbus, OH, United States.
Chao GuoHuman Nutrition Program, The Ohio State University, Columbus, OH, United States.
Menuka BhandariResearch and Analytical Core, College of Food, Agricultural, and Environmental Sciences, The Ohio State University, Wooster, OH, United States.
Matthew D TeegardenFoods for Health Research Initiative, The Ohio State University, Columbus, OH, United States.
Devin G PetersonDepartment of Food Science and Technology, The Ohio State University, Columbus, OH, United States.
Xiaokui MoDepartment of Biomedical Informatics, Center for Biostatistics, The Ohio State University, Columbus, OH, United States.
Jiangjiang ZhuHuman Nutrition Program, The Ohio State University, Columbus, OH, United States.
Richard S BrunoHuman Nutrition Program, The Ohio State University, Columbus, OH, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background/hypothesis: Whole grain intake is associated with reduced risk of type 2 diabetes, yet inconsistent findings from randomized trials and substantial interindividual variability suggest that gut microbiota may influence glycemic responses. We hypothesized that whole wheat bread would improve glucose tolerance compared with refined white bread under controlled feeding conditions in adults with prediabetes, and that gut microbial features would be associated with variability in glycemic response. Methods: In this randomized, controlled crossover trial, adults with prediabetes ( Results: Compared with WHITE, WHEAT reduced postprandial glucose excursion by 27% ( Conclusion: Whole wheat bread improves postprandial glucose tolerance in adults with prediabetes while exhibiting microbiome-associated variation in glycemic response. These findings support whole wheat as an effective dietary strategy and highlight baseline gut microbial features as key contributors to inter-individual responses, advancing precision nutrition approaches to whole grain consumption. Clinical trials registration: ClinicalTrials.gov: NCT05318183.

Indexed as

crossover trialglucose tolerancegut microbiotaprecision nutritionprediabeteswhole wheat

Identifiers

PMID42729417
PMCPMC13562025

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