Evidence map›Paper›PMID 42729348›Full record

ArticleFrontiers in human neuroscience2026

The impact of transcutaneous tibial nerve stimulation on brain function in patients with overactive bladder: a prospective longitudinal self-controlled study.

Ziyu Wang, Yuansong Xiao, Xiangjun Lyu, Han Deng, Chen Li, Dongsheng Shang, Linquan Jin, Limin Liao, Yun Guo, Xing Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in human neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ziyu Wang *Department of Urology, Rehabilitation School of Capital Medical University, China Rehabilitation Research Center, Beijing, China.
Yuansong Xiao *Department of Urology, General Hospital of Southern Theater Command, Guangzhou, China.
Xiangjun Lyu *Department of Urology, The Third Medical Center of Chinese PLA General Hospital, Beijing, China.
Han DengDepartment of Urology, Rehabilitation School of Capital Medical University, China Rehabilitation Research Center, Beijing, China.
Chen LiDepartment of Urology, Rehabilitation School of Capital Medical University, China Rehabilitation Research Center, Beijing, China.
Dongsheng ShangDepartment of Rehabilitation, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Linquan JinDepartment of Rehabilitation, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Limin LiaoDepartment of Urology, Rehabilitation School of Capital Medical University, China Rehabilitation Research Center, Beijing, China.
Yun GuoDepartment of Rehabilitation Medicine, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, Beijing, China.
Xing LiDepartment of Urology, Rehabilitation School of Capital Medical University, China Rehabilitation Research Center, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This study aimed to explore brain activity and functional connectivity changes associated with transcutaneous tibial nerve stimulation (TTNS) in patients with neurogenic overactive bladder (OAB), alongside changes in clinical symptoms. Methods: This prospective longitudinal self-controlled trial, conducted at the China Rehabilitation Research Center from 2024 to 2025, enrolled 15 adults with symptom-defined neurogenic OAB associated with spinal cord injury or multiple sclerosis. Resting-state functional magnetic resonance imaging (fMRI) was performed before and after standardized TTNS under full- and empty-bladder conditions. The primary imaging outcomes were fractional amplitude of low-frequency fluctuations (fALFF) and functional connectivity (FC). Results: TTNS significantly enhanced clinical outcomes, reducing 24 h urinary frequency from 15.53 ± 2.97 to 12.87 ± 2.88 ( Conclusion: In this cohort, 1 month of TTNS was associated with reductions in urinary frequency and OABSS and with changes in fALFF and FC. These preliminary findings do not establish neuroplasticity, normalization, or a causal TTNS-specific mechanism and require confirmation in adequately powered sham-controlled studies. Clinical trial registration: https://www.chictr.org.cn/hvshowprojectEN.html?id=300046&v=1.0, Identifier: ChiCTR2600122960.

Indexed as

fractional amplitude of low-frequency fluctuationsfunctional connectivityfunctional magnetic resonance imagingoveractive bladdertranscutaneous tibial nerve stimulation

Identifiers

PMID42729348
PMCPMC13562249

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.