Evidence map›Paper›PMID 42729274›Full record

ArticleFrontiers in bioengineering and biotechnology2026

Subject-specific kinematic analysis of a total ankle arthroplasty implant.

Vincenzo Leone, Antonio Mazzotti, Cesare Faldini, Simone Ottavio Zielli, Francesca Di Puccio, Marco Viceconti, Cristina Curreli

Abstract read
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Vincenzo LeoneMedical Technology Lab, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
Antonio Mazzotti1st Orthopaedic and Traumatologic Clinic, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
Cesare Faldini1st Orthopaedic and Traumatologic Clinic, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
Simone Ottavio Zielli1st Orthopaedic and Traumatologic Clinic, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.
Francesca Di PuccioDepartment of Civil and Industrial Engineering, University of Pisa, Pisa, Italy.
Marco VicecontiDepartment of Industrial Engineering, Alma Mater Studiorum - University of Bologna, Bologna, Italy.
Cristina CurreliMedical Technology Lab, IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Total Ankle Arthroplasty (TAA) is a well-established surgical treatment for end-stage ankle arthritis, yet functional outcomes often remain inferior to those of the native joint. This may be because restoring the full physiological range of motion would likely require a custom-made surgery, in which both the prosthetic design and component positioning are defined on the basis of a patient-specific kinematic analysis. The aim of this study is to propose a subject-specific kinematic analysis of an ankle joint implanted with the FAR prosthesis and to investigate the compatibility between prosthesis-induced motion and the physiological motion of the healthy joint. A CT-based 3D model and a 4-bar linkage model were used to estimate the physiological path of the instantaneous centre of rotation during passive plantar-dorsiflexion, while the kinematic constraints of the FAR prosthesis were simultaneously analysed. A novel methodology was proposed, based on an analogy between the FAR implant design and a planetary gear mechanism, to reproduce the physiological kinematics of the natural joint with high fidelity. The results, in terms of overall plantar-dorsiflexion range of motion and ligament behaviour, suggested that the analysed TAA design was unable to fully reproduce the physiological kinematics of the healthy joint model for the subject and virtual surgery considered. Comparison with clinical data demonstrated general agreement in terms of range of motion and meniscal bearing displacement. Overall, the proposed methodology provides a framework for systematically analysing subject-specific ankle joint kinematics after implantation and suggests promising directions for future research.

Indexed as

4 bar linkageCT-based modelFAR prosthesisplanetary gear mechanismsubject-specific kinematicstotal ankle arthroplasty

Identifiers

PMID42729274
PMCPMC13561990

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.