Evidence map›Paper›PMID 42729266›Full record

ArticleFrontiers in cell and developmental biology2026

Human periodontal ligament stem cells promote oral ulcer healing in rats through modulation of TGF-β1/smad signaling.

Xiang Cai, Guoguo Jin, Wei Wang, Lingyue Wu, Kingsing Tam, Xiaotian Wang, Yue Wang, Huajian Tian, Qi Xiang, Zhiying Zhou

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Xiang Cai *State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, China.
Guoguo Jin *State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, China.
Wei Wang *State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, China.
Lingyue Wu *State Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, China.
Kingsing TamState Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, China.
Xiaotian WangState Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, China.
Yue WangState Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, China.
Huajian TianState Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, China.
Qi XiangState Key Laboratory of Bioactive Molecules and Druggability Assessment, Jinan University, Guangzhou, China.
Zhiying ZhouSchool of Stomatology, Jinan University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Oral ulcers (OU) often present with prolonged healing, recurrent episodes, and scar formation, posing challenges for clinical management. Human periodontal ligament stem cells (hPDLSCs) have shown potential in oral tissue repair, but further research is needed to clarify their mechanism of action in OU healing. This study aims to elucidate the molecular mechanisms by which hPDLSCs promote oral ulcer healing. Method: To identify key regulatory genes, the OU-associated microarray dataset GSE37265 was integrated with hPDLSC genomic data for differential expression analysis. Subsequently, Weighted Gene Co-expression Network Analysis (WGCNA) was used to identify functional modules associated with OU healing. Results: Bioinformatics analysis identified 92 key genes in hPDLSCs-mediated treatment of OU, highlighting the central role of the TGF-β1/Smad pathway. As shown by the animal studies, hPDLSCs therapy increased the healing rate to 97% by day 8 ( Conclusion: In this study, we reveal a novel role for hPDLSCs in promoting oral ulcer healing. The findings indicate that hPDLSCs suppress inflammation and fibrosis via the TGF-β1/Smad pathway, offering a promising therapeutic strategy for OU and other fibrotic conditions.

Indexed as

fibrosishPDLSCsinflammationoral ulcer healingoral ulcersTGF-β1

Identifiers

PMID42729266
PMCPMC13562027

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.