ArticleFrontiers in immunology2026
Zinc and metallothionein dysregulation in B cells in multiple sclerosis, with disease-specific CXCR3
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Multiple sclerosis (MS) is associated with compartmentalized B-cell responses in the cerebrospinal fluid (CSF), where CXCR3 Methods: We reanalyzed two publicly available human single-cell RNA sequencing datasets containing CSF and peripheral blood (PB) B cells from healthy or non-MS controls and patients with clinically isolated syndrome or MS. Zinc transporter and metallothionein (Zn/MT) gene expression was examined in CXCR3 Results: A composite Zn/MT signature was significantly elevated in MS relative to controls in both PB and CSF, and in both CXCR3 Discussion: These findings identify altered zinc-homeostasis pathways as a disease-associated feature of B cells in MS and reveal a disease-specific divergence between CXCR3
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