Evidence map›Paper›PMID 42729228›Full record

ArticleFrontiers in immunology2026

Intratumoral

Juhang Chu, Haitao Huang, Yuheng Hu, Qiaoer Wang, Tao Yuan, Shengyu Huang, Jianbo Lin, Chenxiang He, Haoyu Li, Hao Shen and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Juhang Chu *Department of Hepatobiliary and Pancreatic Surgery, the Tenth People's Hospital of Tongji University, School of Medicine, Tongji University, Shanghai, China.
Haitao Huang *Department of Hepatobiliary and Pancreatic Surgery, the Tenth People's Hospital of Tongji University, School of Medicine, Tongji University, Shanghai, China.
Yuheng Hu *Department of Hepatobiliary and Pancreatic Surgery, the Tenth People's Hospital of Tongji University, School of Medicine, Tongji University, Shanghai, China.
Qiaoer WangDepartment of Hepatobiliary and Pancreatic Surgery, the Tenth People's Hospital of Tongji University, School of Medicine, Tongji University, Shanghai, China.
Tao YuanDepartment of Hepatobiliary and Pancreatic Surgery, the Tenth People's Hospital of Tongji University, School of Medicine, Tongji University, Shanghai, China.
Shengyu HuangDepartment of Hepatobiliary and Pancreatic Surgery, the Tenth People's Hospital of Tongji University, School of Medicine, Tongji University, Shanghai, China.
Jianbo LinDepartment of Hepatobiliary and Pancreatic Surgery, the Tenth People's Hospital of Tongji University, School of Medicine, Tongji University, Shanghai, China.
Chenxiang HeDepartment of Hepatobiliary and Pancreatic Surgery, the Tenth People's Hospital of Tongji University, School of Medicine, Tongji University, Shanghai, China.
Haoyu LiDepartment of Hepatobiliary and Pancreatic Surgery, the Tenth People's Hospital of Tongji University, School of Medicine, Tongji University, Shanghai, China.
Hao ShenClinical Research Institute and Department of Hepatobiliary Surgery, Eastern Hepatobiliary Surgery Hospital and National Centre for Liver Cancer, Naval Medical University, Shanghai, China.
Jun LiDepartment of Hepatobiliary and Pancreatic Surgery, the Tenth People's Hospital of Tongji University, School of Medicine, Tongji University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Colorectal cancer liver metastasis (CRLM) develops in a hepatic niche where tumor cells encounter organ‑specific microbial, metabolic, and immune constraints. The role of intratumoral bacteria in this metastatic ecosystem remains incompletely defined. Methods: We analyzed tumor and peritumoral tissues from 20 patients with non‑metastatic colorectal cancer (CRC) and 20 patients with CRLM by 5R 16S rDNA sequencing, untargeted metabolomics, and functional assays. Public datasets were used for single‑cell analysis of the tumor immune microenvironment. Results: Primary colorectal lesions and paired liver metastases showed distinct microbial structures. Liver metastatic lesions had lower microbial diversity, and 73 genera differed between CRLM primary tumors and liver metastases. Discussion: Together, these findings provide evidence that

Indexed as

Apolipoproteins EBacillusColorectal NeoplasmsLipid MetabolismLiver NeoplasmsMacrophagesTumor-Associated MacrophagesAgedAnimalsCell Line, TumorFemaleHumansMaleMetabolomicsMiceMiddle AgedApolipoproteins EAPOE+ macrophagesBacilluscolorectal cancer liver metastasisintratumoral microbiotalipid metabolic regulationmetabolomicssingle-cell transcriptomicstumor immune microenvironment

Identifiers

PMID42729228
PMCPMC13561942

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.