Evidence map›Paper›PMID 42729209›Full record

ArticleFrontiers in immunology2026

Vitamin C enhances cytotoxicity of CAR-and εTRuC-engineered γδ T cells and modulates Ca

Michal Zarobkiewicz, Lin Ma, Claudia Juraske, Lea Cierna, Léonce Kouakanou, Sonia Maria Krißmer, Gina J Fiala, Christian Peters, Wolfgang W Schamel, Dieter Kabelitz

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In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Michal Zarobkiewicz *Institute of Medical Immunology, Christian-Albrechts University, University Hospital Schleswig-Holstein, Kiel, Germany.
Lin Ma *Signalling Research Centres BIOSS and CIBSS, Faculty of Biology, University of Freiburg, Freiburg, Germany.
Claudia Juraske *Signalling Research Centres BIOSS and CIBSS, Faculty of Biology, University of Freiburg, Freiburg, Germany.
Lea Cierna *Institute of Medical Immunology, Christian-Albrechts University, University Hospital Schleswig-Holstein, Kiel, Germany.
Léonce KouakanouInstitute of Medical Immunology, Christian-Albrechts University, University Hospital Schleswig-Holstein, Kiel, Germany.
Sonia Maria KrißmerSignalling Research Centres BIOSS and CIBSS, Faculty of Biology, University of Freiburg, Freiburg, Germany.
Gina J FialaSignalling Research Centres BIOSS and CIBSS, Faculty of Biology, University of Freiburg, Freiburg, Germany.
Christian PetersInstitute of Medical Immunology, Christian-Albrechts University, University Hospital Schleswig-Holstein, Kiel, Germany.
Wolfgang W SchamelSignalling Research Centres BIOSS and CIBSS, Faculty of Biology, University of Freiburg, Freiburg, Germany.
Dieter KabelitzInstitute of Medical Immunology, Christian-Albrechts University, University Hospital Schleswig-Holstein, Kiel, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

γδ T cells have raised interest as effector cells in cancer immunotherapy, due to their broad and HLA-independent reactivity towards multiple tumor entities. Despite promising ongoing clinical studies, there is a need to improve the effector function and thereby the efficacy of γδ T cells. In addition to its role as anti-oxidant, Vitamin C is an epigenetic modifier and exerts multiple effects on T-cell differentiation. While Vitamin C enhances

Indexed as

Ascorbic AcidCytotoxicity, ImmunologicReceptors, Antigen, T-Cell, gamma-deltaReceptors, Chimeric AntigenT-LymphocytesCalciumHumansImmunotherapy, AdoptiveMAP Kinase Signaling SystemNFATC Transcription FactorsNF-kappa BSignal TransductionAscorbic AcidCalciumNFATC Transcription FactorsNF-kappa BReceptors, Antigen, T-Cell, gamma-deltaReceptors, Chimeric Antigenadoptive cell therapyCARimmunotherapyTRuCvitamin Cγδ T cells

Identifiers

PMID42729209
PMCPMC13561771

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.