ArticleTranslational andrology and urology2026
Effects of a commercial lemonade beverage, potassium citrate, and combination therapy on urinary stone risk parameters in hypocitraturic stone formers: a randomized crossover trial.
Article in Translational andrology and urology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05389995 (Assessing the Effects of a Commercial Lemonade Beverage and Potassium Citrate on Urinary Stone Risk Factors), which is not on this map. Not yet cited in PubMed.
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Assessing the Effects of a Commercial Lemonade Beverage and Potassium Citrate on Urinary Stone Risk Factors
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6 authors.
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Abstract
Background: Potassium citrate (KCit) is commonly prescribed to patients with recurrent nephrolithiasis; however, medication compliance is poor due to gastrointestinal side-effects. Crystal Light Methods: We performed a randomized crossover trial of 8 patients with isolated hypocitraturia on 24-hour urine collections. Patients completed three 1-week trials of KCit (15 mEq daily), CL (1 L daily), and combination CL and KCit (500 mL + 10 mEq daily) followed by immediate 24-hour urine collections after each weekly treatment. There was a washout period of 1 week in between each regimen. Statistical analysis was conducted with Kruskal-Wallis rank sum tests and linear mixed-effects models. Results: The CL regimen led to the greatest increases in urinary volume (CL: 0.53 Conclusions: In this limited study in active stone formers with hypocitraturia, consumption of a low-calorie sugar-free citrate-containing lemonade beverage was well tolerated with no reported adverse effects. Multi-institutional studies are needed to determine clinical significance. Trial Registration: ClinicalTrials.gov NCT05389995.
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