Evidence map›Paper›PMID 42728852›Full record

ArticleGut microbes2026

Dual screen for gut metabolites suppressing enterobacterial growth and invasiveness reveals structure-activity relationships among anti-infective indoles.

Alexandra Bergholtz, Weifeng Lin, Amanpreet Kaur, Anjeela Bhetwal, Shaochun Zhu, André Mateus, Maria Letizia Di Martino, Jens Eriksson, Daniel Globisch, Mikael E Sellin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alexandra BergholtzDepartment of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.ORCID 0000-0002-1630-4442
Weifeng LinDepartment of Chemistry for Life Sciences, Uppsala University, Uppsala, Sweden.ORCID 0000-0001-8330-7072
Amanpreet KaurDepartment of Chemistry for Life Sciences, Uppsala University, Uppsala, Sweden.
Anjeela BhetwalDepartment of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.
Shaochun ZhuDepartment of Chemistry, Umeå University, Umeå, Sweden.ORCID 0000-0001-9945-6718
André MateusDepartment of Chemistry, Umeå University, Umeå, Sweden.ORCID 0000-0001-6870-0677
Maria Letizia Di MartinoDepartment of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.ORCID 0000-0002-9491-4000
Jens ErikssonDepartment of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.ORCID 0000-0002-8945-2665
Daniel GlobischDepartment of Chemistry for Life Sciences, Uppsala University, Uppsala, Sweden.ORCID 0000-0002-4526-5788
Mikael E SellinDepartment of Medical Biochemistry and Microbiology, Uppsala University, Uppsala, Sweden.ORCID 0000-0002-8355-0803

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The antibiotic resistance crisis has made the characterization of new anti-infective molecules a pressing matter. Molecules that suppress bacterial growth and survival, virulence, or a combination of these traits all warrant further exploration. Naturally occurring microbe‒host ecosystems, such as the human gut, provide incompletely tapped resources in this regard. We developed a flexible platform to parallelly assess how gut metabolites affect the growth and epithelial cell invasion capacity of the enteropathogens

Indexed as

Anti-Bacterial AgentsAnti-Infective AgentsIndolesSalmonella typhimuriumShigella flexneriGastrointestinal MicrobiomeHumansStructure-Activity RelationshipVirulenceAnti-Bacterial AgentsAnti-Infective AgentsIndolesanti-infectivesepitheliumGut metabolitesindoleinvasionmetabolomemethylindoleSalmonellaShigella

Identifiers

PMID42728852
PMCPMC13577278

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.