ReviewClinical and translational medicine2026
Cancer-related pain: A bidirectional modulator of cancer progression.
Review in Clinical and translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Authors and funding
6 authors.
Funding
Abstract
backgroundCancer-related pain (CRP), with a high prevalence and prognostic value in malignancies, is not only a passive phenomenon but rather engages in a bidirectional crosstalk with cancer progression. MAIN TOPICS: This review focuses on the intricate reciprocal relationship between CRP and cancer progression, delineating how advanced cancers promote CRP directly through tissue destruction, invasion and inflammation, or indirectly via inflammatory, neural, stromal and metabolic components within the tumour microenvironment. However, controversies remain in the field, such as the ambiguous role of sensory neurons in cancer progression and the potential pro-tumorigenic risk of opioids. Notably, CRP regulates cancer progression through local pain-associated mediators (e.g., CGRP, SP), the pain-stress axis, central nuclei-mediated peripheral immune modulation, sensory-sympathetic/vagal circuits and direct effects on tumour biology.
conclusionFuture research should further elucidate the mechanistic interplay between pain and cancer, as targeting CRP may offer novel therapeutic opportunities for anti-cancer treatment. HIGHLIGHTS: CRP and tumour progression engage in a dynamic, bidirectional circuit mediated by multiple mechanisms in neuroimmunology and cancer neuroscience. Analgesic interventions may affect tumour progression, while anticancer therapies can influence pain. Targeting pain in cancer may have promising therapeutic value in cancer progression.
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