ArticleAAPS PharmSciTech2026
Degree of Carboxymethyl Substitution on Tara Gum Influences the Mucoadhesive and Physicochemical Performance of Gastroretentive Tablets.
Article in AAPS PharmSciTech, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The present study investigates the effect of the degree of carboxymethyl substitution in tara gum (TG) on the physicochemical and mucoadhesive properties of gastroretentive tablets. The synthesis of carboxymethyl TG (CMTG) was optimized under various reaction conditions with respect to degree of substitution (DS). The DS varied from 0.47 ± 0.002 to 1.14 ± 0.014 depending on the reaction conditions. The DS significantly influenced the flow properties, swelling behavior, and erosion of the tablets. Ex vivo mucoadhesion studies on goat stomach mucosa revealed that both mucoadhesive strength (MS) and mucoadhesive time (MT) varied with changes in DS. MS and MT progressively increased from 45.51 × 10
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