Evidence map›Paper›PMID 42728305›Full record

Trial reportSpinal cord series and cases2026

Postural changes and motor evoked potentials following percutaneous spinal cord epidural stimulation in spinal cord injury.

Sohale Hessavi, Will Schroeder, Ahmad Alazzam, Muhammad Uzair Rehman, Robert Trainer, Ashraf S Gorgey

Abstract readClinical Trial, Phase IIClinical Trial, Phase IIIRandomized Controlled Trial
In one paragraph

Trial report in Spinal cord series and cases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sohale HessaviSchool of Medicine, Virginia Commonwealth University, Richmond, VA, 23284, USA.
Will SchroederSchool of Medicine, Virginia Commonwealth University, Richmond, VA, 23284, USA.
Ahmad AlazzamSpinal Cord Injury and Disorders Center, Richmond VA Medical Center, Richmond, VA, 23249, USA.
Muhammad Uzair RehmanSpinal Cord Injury and Disorders Center, Richmond VA Medical Center, Richmond, VA, 23249, USA.
Robert TrainerPhysical Medicine and Rehabilitation, Richmond VA Medical Center, Richmond, VA, 23249, USA.
Ashraf S GorgeySpinal Cord Injury and Disorders Center, Richmond VA Medical Center, Richmond, VA, 23249, USA. ashraf.gorgey@va.gov.ORCID http://orcid.org/0000-0002-9157-6034

Funding

DOD | Congressionally Directed Medical Research Programs (CDMRP) W81XWH2010845
6 · The paper itself

Abstract

introductionPercutaneous spinal cord epidural stimulation (pSCES) is an effective modality for managing pain. However, the use of pSCES in restoration of motor control after SCI is still under research exploration. Today, the effects of postural changes on pSCES-motor control are still controversial. CASE PRESENTATION: Two participants with complete SCI underwent implantation of pSCES. The motor recruitment curves of motor units of two different agonist-antagonist muscle groups were captured in a supine position and in a standing position using a standing frame. The amplitudes of the motor evoked response were presented in absolute or relative to the maximum response. Both narrow and wide field pSCES configurations elicited intensity-dependent EMG responses across lower-limb muscles, with substantially greater amplitudes in supine compared to standing. Transitioning to standing produced marked bilateral attenuation of raw responses across muscles and configurations, although relative recruitment patterns were partially preserved following EMG normalization. Increasing pulse duration broadened relative muscle recruitment and enhanced distal muscle activation, but posture remained the dominant determinant of overall response magnitude. DISCUSSION: Standing posture was associated with substantial attenuation of pSCES-evoked responses across muscles and stimulation parameters, indicating posture-dependent modulation of evoked muscle activation following pSCES implantation in persons with SCI.

Indexed as

Evoked Potentials, MotorPostureSpinal Cord InjuriesSpinal Cord StimulationAdultElectromyographyFemaleHumansMaleMuscle, Skeletal

Identifiers

PMID42728305
PMCPMC13569841

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.