Evidence map›Paper›PMID 42728266›Full record

ArticleNature communications2026

Urban exposures, frailty, and mental illness in World Trade Center Health Program responders.

Helena Krasnov, William Hung, Pablo Knobel, Itai Kloog, Fred Ko, Hannah Thompson, Elena Colicino, Susan L Teitelbaum, Allan C Just, Maayan Yitshak-Sade

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Long-term Exposure to PMmedRxiv : the preprint server for health sciences · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Helena KrasnovDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. helena.furman@mssm.edu.ORCID http://orcid.org/0000-0003-0230-3112
William HungGeriatrics and Palliative Care, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Pablo KnobelDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Itai KloogDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Fred KoGeriatrics and Palliative Care, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Hannah ThompsonDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Elena ColicinoDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-1875-8448
Susan L TeitelbaumDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Allan C JustDepartment of Epidemiology, Brown University School of Public Health, Providence, RI, USA.
Maayan Yitshak-SadeDepartment of Environmental Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

Funding

Residing in the Community with Dementia at the End of Life: Understanding Hospice Use and Residential SettingP30AG028741 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI William W.,MPH, MD Hung · 2010 to 2026
$21.9M
The Mount Sinai Transdisciplinary Center on Early Environmental ExposuresP30ES023515 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Chris Gennings · 2014 to 2026
$21.3M
Institutional Career Development CoreKL2TR004421 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Inga Peter · 2022 to 2026
$6.2M
Cardiometabolic diseases in the World Trade Center general responder cohort and the role of subsequent environmental exposuresR01ES034864 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Maayan Yitshak Sade · 2023 to 2026
$1.9M
NCATS NIH HHS KL2 TR004421NIA NIH HHS P30 AG028741NIEHS NIH HHS P30 ES023515NIEHS NIH HHS R01 ES034864NIOSH CDC HHS U01 OH012473NIOSH CDC HHS U10 OH008216
6 · The paper itself

Abstract

General responders of the World Trade Center Health Program were uniquely exposed to chemical toxicants and extreme psychological stress during the 2001 terrorist attack, and now experience unusually prevalent health outcomes for a mid-aged population, including frailty, Post Traumatic Stress Disorder, and depression. We study whether these conditions are linked to later-life urban environmental exposures among 18,734 responders, evaluating associations with annual fine particulate matter, temperature, and Green View Index. A decile incremental increase in the overall exposure-mixture is associated with increased frailty (0.56%; 95% CI: 0.14%;0.98%) and Post Traumatic Stress Disorder scores (0.31%; 95% CI: 0.07%;0.55%). Effects are more pronounced among responders with higher World Trade Center exposures, suggesting increased vulnerability. Here, we show that urban environmental exposures compound the chronic health burden in World Trade Center responders, with effects possibly amplified by World Trade Center exposure history. This suggests that a history of trauma and toxicant exposure can create lasting biological vulnerability to subsequent environmental stressor.

Indexed as

Emergency RespondersEnvironmental ExposureMental DisordersSeptember 11 Terrorist AttacksStress Disorders, Post-TraumaticFemaleHumansMaleNew York CityParticulate MatterParticulate Matter

Identifiers

PMID42728266
PMCPMC13569852

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.