Evidence map›Paper›PMID 42728261›Full record

ArticleScientific reports2026

Mapping a sustainable approach with whey-biosynthesized silver nanocomposites versus chemically synthesized silver nanoparticles in a chronic hippocampal toxicity rat model.

Enas B El Fadly, Doaa H Assar, Abdalla S Salah, Mona Assas, Nancy A Elsayes, Hoda R Noufal, Nesma S Abdelatty, Eman F Khamis, Nesma M El-Kemary, Azza M ElBaz and 1 more

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Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Enas B El FadlyDepartment of Dairy Sciences, Faculty ofAgriculture, KFS University, Kafrelshiekh, Egypt. ebahgat@illinois.edu.ORCID 0000-0002-3406-7284
Doaa H AssarClinical Pathology Department, Faculty of Veterinary Medicine, KFS University, Kafrelshiekh, Egypt.
Abdalla S SalahFish Processing and Biotechnology Department, Aquatic and Fisheries Sciences Faculty, KFS University, Kafrelshiekh, Egypt.
Mona AssasFish Processing and Biotechnology Department, Aquatic and Fisheries Sciences Faculty, KFS University, Kafrelshiekh, Egypt.
Nancy A ElsayesFish Processing and Biotechnology Department, Aquatic and Fisheries Sciences Faculty, KFS University, Kafrelshiekh, Egypt.
Hoda R NoufalFish Processing and Biotechnology Department, Aquatic and Fisheries Sciences Faculty, KFS University, Kafrelshiekh, Egypt.
Nesma S AbdelattyDepartment of Dairy Sciences, Faculty ofAgriculture, KFS University, Kafrelshiekh, Egypt.
Eman F KhamisDepartment of Dairy Chemistry, Animal Production Research Institute, Agricultural Research Center, Gizza, Egypt.
Nesma M El-KemaryDepartment of Microbiology and Immunology, Faculty of Pharmacy, Kafrelsheikh University, Kafrelshiekh, Egypt.
Azza M ElBazDepartment of Dairy Microbiology, Animal Production Research Institute, Agricultural Research Center, Gizza, Egypt.
Zizy I ElbialyFish Processing and Biotechnology Department, Aquatic and Fisheries Sciences Faculty, KFS University, Kafrelshiekh, Egypt. zeze_elsayed@fsh.kfs.edu.eg.

Funding

Enas B. El.Fadly received funding from The Scientific Technology and Cooperation Center, Academy of the Scientific Research and Technology, Cairo, Egypt 33/2018.
6 · The paper itself

Abstract

Silver nanoparticles (AgNPs) are increasingly utilized in food-contact materials and dairy processing systems. However, the chronic oral effects of these materials have not been sufficiently characterized. This study compared hippocampal responses to chemically synthesized AgNPs (8-11 nm) suspended in whey-based medium (WBM) at measured silver concentrations with those from biogenic silver nanocomposites (AgNCs; 13.3 ± 3.6 nm). These were administered orally to male Sprague-Dawley rats (120-150 g, n = 5 per group) for 90 days. AgNCs were biosynthesized by fermenting WBM with Lactobacillus acidophilus using 4 mM or 6 mM AgNO

Indexed as

HippocampusMetal NanoparticlesNanocompositesSilverWheyAnimalsApoptosisLactobacillus acidophilusMaleOxidative StressRatsRats, Sprague-DawleySilverApoptosisBiogenic silver nanocompositesHippocampal neurotoxicityNF-κB/Nrf2/caspase-3 pathwayOxidative stress

Identifiers

PMID42728261
PMCPMC13569854

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.