Evidence map›Paper›PMID 42727343›Full record

ArticlePoultry science2026

Pigeon employs a conserved IRF7 gene to mediate innate immune response.

Qi Shao, Qiuju Liu, Jie Wang, Shuhan Li, Zhaofei Wang, Jingjiao Ma, Hengan Wang, Yaxian Yan, Yuqiang Cheng, Jianhe Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Poultry science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Qi ShaoSchool of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai Key Laboratory of Veterinary Biotechnology, Agriculture Ministry Key Laboratory of Urban Agriculture (South), Shanghai 200240, China.
Qiuju LiuSchool of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai Key Laboratory of Veterinary Biotechnology, Agriculture Ministry Key Laboratory of Urban Agriculture (South), Shanghai 200240, China.
Jie WangSchool of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai Key Laboratory of Veterinary Biotechnology, Agriculture Ministry Key Laboratory of Urban Agriculture (South), Shanghai 200240, China.
Shuhan LiShandong Provincial Key Laboratory of Zoonoses, Sino-German Cooperative Research Centre for Zoonosis of Animal Origin of Shandong Province, College of Veterinary Medicine, Shandong Agricultural University, 61 Daizong Street, Tai'An 271018, China.
Zhaofei WangSchool of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai Key Laboratory of Veterinary Biotechnology, Agriculture Ministry Key Laboratory of Urban Agriculture (South), Shanghai 200240, China.
Jingjiao MaSchool of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai Key Laboratory of Veterinary Biotechnology, Agriculture Ministry Key Laboratory of Urban Agriculture (South), Shanghai 200240, China.
Hengan WangSchool of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai Key Laboratory of Veterinary Biotechnology, Agriculture Ministry Key Laboratory of Urban Agriculture (South), Shanghai 200240, China.
Yaxian YanSchool of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai Key Laboratory of Veterinary Biotechnology, Agriculture Ministry Key Laboratory of Urban Agriculture (South), Shanghai 200240, China.
Yuqiang ChengSchool of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai Key Laboratory of Veterinary Biotechnology, Agriculture Ministry Key Laboratory of Urban Agriculture (South), Shanghai 200240, China.
Jianhe SunSchool of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai Key Laboratory of Veterinary Biotechnology, Agriculture Ministry Key Laboratory of Urban Agriculture (South), Shanghai 200240, China. Electronic address: sunjhe@sjtu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Compared with chickens and ducks, pigeons exhibit higher resistance to RNA virus infection. Interferon regulatory factor 7 (IRF7) was identified a member of the interferon regulatory factors (IRFs) family, which plays an important role in innate immune response. Subsequent studies have shown that IRF7 performs a diverse function in multiple biological processes. In this study, pigeon IRF7 (piIRF7) was first cloned, and bioinformatics analysis showed that IRF7 varies among species, but the IRF and IRF3 domains are highly conserved. Further study showed that only NDV infection upregulated IRF7 mRNA levels in vivo, and NDV, AIV, FPV infection, and nucleic acids mimic stimulation also significantly upregulated piIRF7 mRNA levels in PEFs. Furthermore, overexpressing piIRF7 promoted IFNs and IFN-stimulated genes (ISGs) activation and inhibited NDV and VSV replication. Importantly, we observed that pigeon and chicken IRF7 suppressed viral replication more efficiently than human and bat IRF7 in IRF7

Indexed as

Innate immunityInterferon regulatory factor 7PigeonViral replication

Identifiers

PMID42727343
PMCPMC13589148

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.