Repeated hypergravity training facilitates vestibular compensation associated with dorsal root ganglion remodeling.

Yuta Masuda, Kakeru Shimizu, Marina Khatun, Sajjad Hossain, Risa Shimane, Nanaka Tameike, Yukari Takeda, Chikara Abe

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Article in The journal of physiological sciences : JPS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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8 authors.

Yuta MasudaDepartment of Physiology, University of Fukui Faculty of Medical Sciences, Fukui, Japan.

Kakeru ShimizuDepartment of Physiology, University of Fukui Faculty of Medical Sciences, Fukui, Japan.

Marina KhatunDepartment of Physiology, University of Fukui Faculty of Medical Sciences, Fukui, Japan; Department of Biochemistry and Molecular Biology, Faculty of Life Science, Mawlana Bhashani Science and Technology University, Bangladesh.

Sajjad HossainDepartment of Physiology, University of Fukui Faculty of Medical Sciences, Fukui, Japan.

Risa ShimaneDepartment of Physiology, University of Fukui Faculty of Medical Sciences, Fukui, Japan.

Nanaka TameikeDepartment of Physiology, University of Fukui Faculty of Medical Sciences, Fukui, Japan.

Yukari TakedaDepartment of Physiology, University of Fukui Faculty of Medical Sciences, Fukui, Japan.

Chikara AbeDepartment of Physiology, University of Fukui Faculty of Medical Sciences, Fukui, Japan. Electronic address: chikara@u-fukui.ac.jp.

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6 · The paper itself

Abstract

Vestibular compensation relies on sensory reweighting, but whether repeated hypergravity training (HT) facilitates recovery after bilateral vestibular lesion (BVL) remains unclear. We investigated the effects of HT on motor function and dorsal root ganglion (DRG) transcriptomes in mice following BVL. Mice underwent sham surgery or BVL and were assigned to either HT (2 G, 60 min/day for 10 days) or no HT (NHT). Body weight, righting reflex, and rotarod performance were evaluated, and RNA sequencing of L5 DRGs was performed on day 7. HT did not improve body weight loss or vestibular-dependent righting reflex deficits. However, HT resulted in significantly better rotarod performance on Day 7 compared with NHT. RNA sequencing identified 397 candidate genes, with enrichment of muscle-related and myelination-related biological processes. These findings suggest that repeated HT facilitates vestibular compensation by promoting transcriptional changes in DRGs and enhancing peripheral somatosensory plasticity rather than restoring vestibular function itself.

Indexed as

Dorsal root ganglionHypergravitySomatosensory plasticityVestibular compensationVestibular lesion

Identifiers

PMID42727320

DOI10.1016/j.jphyss.2026.100100

PMCPMC13589081

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.