Evidence map›Paper›PMID 42727217›Full record

ArticleJACC. Basic to translational science2026

Impact of Respiratory Mechanics on Venous Return in Single Ventricle Physiology: A Clinical Imaging Study.

Markus A Horvath, Jean Bonnemain, Andreas Escher, David Van Story, Bryce Starr, Mulan Jiang, Emilia Herdes, David Annese, Breanna Piekarski, Stephanie Agudelo and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACC. Basic to translational science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. The Fontan Circulation: When Net Flow Is Not the Whole Story.JACC. Basic to translational science · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Markus A HorvathInstitute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA; Boston Children's Hospital, Boston, Massachusetts, USA.
Jean BonnemainInstitute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA; Department of Adult Intensive Care Medicine, Lausanne University Hospital and University of Lausanne, Lausanne, Canton of Vaud, Switzerland.
Andreas EscherInstitute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
David Van StoryInstitute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Bryce StarrInstitute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA.
Mulan JiangInstitute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Emilia HerdesInstitute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
David AnneseBoston Children's Hospital, Boston, Massachusetts, USA.
Breanna PiekarskiBoston Children's Hospital, Boston, Massachusetts, USA.
Stephanie AgudeloBoston Children's Hospital, Boston, Massachusetts, USA.
Kinsey BrassawBoston Children's Hospital, Boston, Massachusetts, USA.
Maria ValenzaBoston Children's Hospital, Boston, Massachusetts, USA.
Andrew PowellBoston Children's Hospital, Boston, Massachusetts, USA.
Pedro J Del NidoBoston Children's Hospital, Boston, Massachusetts, USA.
Ellen T RocheInstitute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA; Boston Children's Hospital, Boston, Massachusetts, USA; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA. Electronic address: etr@mit.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In participants with single-ventricle physiology, it is unclear how respiratory mechanics affects venous return. The aim of this study was to evaluate the impact of respiratory effort and rate on venous return. We used magnetic resonance imaging to quantify flow in the inferior vena cava (IVC) in 20 participants with total cavopulmonary connection during a breathing study (shallow, baseline, deep, and slow, baseline, fast). Retrograde IVC flow rate, forward IVC flow rate, retrograde flow ratio, forward IVC flow volume, retrograde IVC flow volume, and pulsatility index were extracted. Increases in respiratory effort or rate increased retrograde flow and pulsatility.

Indexed as

fontan circulationMRIpulsatilityretrograde flowsingle ventricle physiologyvenous return

Identifiers

PMID42727217
PMCPMC13589073

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.