Evidence map›Paper›PMID 42726878›Full record

ArticleScience advances2026

Herpesviruses hijack ISGylation to promote viral capsid assembly.

Shutong Li, Shu Feng, Yongzhen Liu, Chao Qin, Jianglin Zhang, Takeru Saito, Xinchi Xie, Wen Fu, Rui Wang, Yue Zheng and 10 more

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Shutong LiSection of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089, USA.ORCID 0000-0001-7378-5740
Shu FengDepartment of Microbial Sciences in Health, Global Center for Pathogen and Human Health Research, Cleveland Clinic Research, Cleveland, OH 44106, USA.ORCID 0000-0002-5372-4497
Yongzhen LiuSection of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089, USA.ORCID 0009-0002-1686-7752
Chao QinSection of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089, USA.ORCID 0000-0003-0393-1751
Jianglin ZhangSection of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089, USA.ORCID 0009-0005-3847-8661
Takeru SaitoSection of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089, USA.
Xinchi XieSection of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089, USA.ORCID 0000-0001-5703-2589
Wen FuSection of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089, USA.
Rui WangSection of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089, USA.ORCID 0000-0002-4119-8274
Yue ZhengDepartment of Chemistry and Biological Sciences, Dornsife College of Arts, Letters and Sciences, University of Southern California, Los Angeles, CA 90089, USA.
Zhenfeng ShuSection of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089, USA.
Wayne YehSection of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089, USA.ORCID 0000-0002-4477-1523
Sean SasakiSection of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089, USA.ORCID 0009-0001-7205-8274
Natalia TjokroSection of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089, USA.ORCID 0009-0006-0960-9797
Lin ChenDepartment of Chemistry and Biological Sciences, Dornsife College of Arts, Letters and Sciences, University of Southern California, Los Angeles, CA 90089, USA.ORCID 0000-0003-4798-6199
Joshua MungerDepartment of Biochemistry and Biophysics, University of Rochester, Rochester, NY 14642, USA.ORCID 0000-0001-5379-9440
Weiming YuanDepartment of Immunology and Immunotherapeutics, University of Southern California, Los Angeles, CA 90089, USA.ORCID 0000-0002-4780-7157
Jae JungDepartment of Microbial Sciences in Health, Global Center for Pathogen and Human Health Research, Cleveland Clinic Research, Cleveland, OH 44106, USA.ORCID 0000-0003-4559-8774
Casey ChenSection of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089, USA.ORCID 0000-0002-0331-0181
Pinghui FengSection of Infection and Immunity, Herman Ostrow School of Dentistry, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089, USA.ORCID 0000-0002-8494-0205

Funding

Explore roles of HSV-1 in Alzheimer's disease using mouse modelsR01AG070904 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, CASEY, FENG, PINGHUI · 2021 to 2025
$3.9M
Regulated cGAS activation in HSV-1-associated neuropathogenesis.RF1AG088625 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI FENG, PINGHUI · 2025 to 2025
$3.4M
Explore a key nucleotide synthesis enzyme to develop a broad-spectrum antiviral therapy.R01AI184716 · NIAID · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Pinghui Feng, Chao Zhang · 2025 to 2026
$1.6M
Targeting IKKepsilon-mediated nucleotide synthesis in KSHV-associated lymphomaR01CA285192 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Pinghui Feng · 2023 to 2026
$1.5M
NCI NIH HHS R01 CA285192NIAID NIH HHS R01 AI184716NIA NIH HHS R01 AG070904NIA NIH HHS RF1 AG088625
6 · The paper itself

Abstract

Herpesviruses are common pathogens of the oral cavity, yet how they interact with other oral microbes are poorly understood. Using murine gamma-herpesvirus 68 (MHV68) as a model for human gamma-herpesviruses, we find that ISGylation is hijacked to facilitate viral capsid assembly and lytic replication. Coinfection with the oral

Indexed as

CapsidCytokinesHerpesviridaeUbiquitinsVirus AssemblyAnimalsCapsid ProteinsHerpesviridae InfectionsHumansMiceVirus ReplicationCapsid ProteinsCytokinesG1p2 protein, mouseUbiquitins

Identifiers

PMID42726878
PMCPMC13564802

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.