In one paragraphArticle in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
23 authors.
Tony KellyInstitute for Experimental Epileptology and Cognition Research, Medical Faculty, University of Bonn, Bonn, Germany.ORCID 0000-0001-6066-0455 Juan Eduardo Rodriguez-GaticaInstitute for Experimental Epileptology and Cognition Research, Medical Faculty, University of Bonn, Bonn, Germany.ORCID 0000-0003-4123-0104 Carlos Wert-CarvajalInstitute for Experimental Epileptology and Cognition Research, Medical Faculty, University of Bonn, Bonn, Germany.
Niclas CissewskiInstitute for Experimental Epileptology and Cognition Research, Medical Faculty, University of Bonn, Bonn, Germany.
Michela BarboniInstitute for Experimental Epileptology and Cognition Research, Medical Faculty, University of Bonn, Bonn, Germany.
Philipp BethgeInterdisciplinary Institute for Neuroscience, UMR 5297 CNRS, Université de Bordeaux, Bordeaux, France.ORCID 0000-0003-4022-0844 Christin M GodaleDepartment of Anesthesia, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Sarah YaserDepartment of Anesthesia, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID 0009-0005-0671-747X Michel K HerdeInstitute of Cellular Neurosciences, Medical Faculty, University of Bonn, Bonn, Germany.ORCID 0000-0002-2324-2083 Jens TillmannInstitute for Experimental Epileptology and Cognition Research, Medical Faculty, University of Bonn, Bonn, Germany.ORCID 0000-0002-3030-1571 Sabrina Ingrid PeterDepartment of Neurology, Department of Epileptology, RWTH Uniklinik, RWTH Aachen, Aachen, Germany.ORCID 0009-0005-2169-3939 Sebastian DuprazAxonal Growth and Regeneration Group, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.ORCID 0000-0003-4557-2611 Henner KochDepartment of Neurology, Department of Epileptology, RWTH Uniklinik, RWTH Aachen, Aachen, Germany.ORCID 0000-0002-6883-3071 Frank BradkeAxonal Growth and Regeneration Group, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany.ORCID 0000-0002-0345-3772 Steve C DanzerDepartment of Anesthesia, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.ORCID 0000-0003-4405-2999 Tatjana TchumatchenkoInstitute for Experimental Epileptology and Cognition Research, Medical Faculty, University of Bonn, Bonn, Germany.ORCID 0000-0001-9137-809X Martin K SchwarzInstitute for Experimental Epileptology and Cognition Research, Medical Faculty, University of Bonn, Bonn, Germany.
Ulrich KubitscheckClausius-Institute of Physical and Theoretical Chemistry, University of Bonn, Bonn, Germany.ORCID 0000-0003-3750-5355 U Valentin NägerlInterdisciplinary Institute for Neuroscience, UMR 5297 CNRS, Université de Bordeaux, Bordeaux, France.ORCID 0000-0001-6831-9008 Heinz BeckInstitute for Experimental Epileptology and Cognition Research, Medical Faculty, University of Bonn, Bonn, Germany.ORCID 0000-0002-8961-998X Funding
mTOR regulation of aberrant neuronal integration and epileptogenesis in epilepsyR01NS062806 · NINDS · CINCINNATI CHILDRENS HOSP MED CTR · PI DANZER, STEVE C · 2009 to 2019
$3.6MNINDS NIH HHS R01 NS062806
6 · The paper itselfAbstract
For nearly 150 years, textbooks have described dendritic morphology as optimized for efficient synaptic voltage transfer from spines to the soma, implemented as a tubular design respecting Rall's 3/2 rule for impedance matching at branch points. Here, we reveal that this view is an oversimplification. Using multiple high-resolution imaging techniques, we demonstrate that dendrites in cortical and hippocampal neurons exhibit nanoscale constrictions, termed dendritic shaft constrictions (DSCs), with diameters ranging from ∼100 to 500 nanometers in mice. We also identified DSCs in human hippocampal and cortical neurons. We provide theoretical and experimental lines of evidence that these constrictions effectively partition the dendrite into distinct electrical compartments, shaping dendritic integration of synaptic potentials.
Indexed as
DendritesNeuronsSynapsesAnimalsHippocampusHumansMice
Identifiers
PMID42726865
PMCPMC13564900
What OpenQuestion holds
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