In one paragraphArticle in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
9 authors.
Yue WuKey Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, P. R. China.ORCID 0009-0004-2685-8395 Meiling ZhaoKey Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, P. R. China.
Menglan WuKey Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, P. R. China.
Jialiang HuangKey Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, P. R. China.
Yutao ZhangKey Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, P. R. China.ORCID 0009-0008-6343-8778 Chenxu YanKey Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, P. R. China.ORCID 0000-0001-7130-769X Wei-Hong ZhuKey Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, P. R. China.ORCID 0000-0001-9103-166X Zhiqian GuoKey Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, P. R. China.ORCID 0000-0002-2192-825X Yisheng XuKey Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Institute of Fine Chemicals, School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai 200237, P. R. China.ORCID 0000-0001-8245-9787 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Conventional photothermal nanotheranostics suffer from fluorescence quenching caused by energy transfer between imaging and photothermal agents. Although unimolecular nanotheranostic systems circumvents the issue, it remains inadequate for generating substantial fluorescence and photothermal effects simultaneously under single-wavelength excitation. Herein, we develop a molecular aggregation engineering strategy by spectrally decoupling the monomeric state for fluorescence from the aggregated state for photothermal conversion within a unimolecular dye nanoplatform, enabling simultaneous theragnostic. We introduce a kinetic assembly method to encapsulate both NIR-II dyes (DQP) and protein in polymers, precisely regulating the aggregated state. Moreover, strong π-π stacking of the aggregated state of DQP drives photothermal effect, which functions as a thermal stimuli trigger for temperature-responsive DQPNPs to achieve charge reduction and size enlargement, promoting intracellular tumor retention, which ultimately improves fluorescence intensity and enhances photothermal efficacy. Such a molecular aggregation engineering strategy ensures precise tuning of the aggregated state of dyes, which realizes a breakthrough for balance NIR-II fluorescence with photothermal effect, supporting personalized and long-term cancer therapy.
Indexed as
CarbocyaninesCarcinoma, HepatocellularFluorescent DyesLiver NeoplasmsPhotothermal TherapyAnimalsCell Line, TumorHumansKineticsMiceCarbocyaninesFluorescent Dyes
Identifiers
PMID42726862
PMCPMC13564911
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