Evidence map›Paper›PMID 42726857›Full record

ArticleScience advances2026

Targeting LOXL4-driven matrix stiffening with acetyldigoxin restores CD8

Xuyu Gu, Yifei Zhu, Li Xu, Xinnan Xu, Kaiqi Jin, William C Cho, Qiyu Fang

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xuyu GuDepartment of Oncology, Shanghai Pulmonary Hospital, School of medicine, Tongji University, Shanghai 200433, China.ORCID 0009-0004-3232-4293
Yifei ZhuDepartment of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.ORCID 0000-0002-7756-2103
Li XuDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, School of medicine, Tongji University, Shanghai 200433, China.
Xinnan XuDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, School of medicine, Tongji University, Shanghai 200433, China.ORCID 0009-0009-2234-2865
Kaiqi JinDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital, School of medicine, Tongji University, Shanghai 200433, China.ORCID 0000-0001-7904-3385
William C ChoDepartment of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong SAR, China.ORCID 0000-0003-4174-4586
Qiyu FangDepartment of Oncology, Shanghai Pulmonary Hospital, School of medicine, Tongji University, Shanghai 200433, China.ORCID 0000-0002-7001-143X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Extracellular matrix (ECM) stiffness is known to impair T cell function, yet the underpinning molecular cascade remains undefined. This paper investigates the role of lysyl oxidase-like 4 (LOXL4) in ECM stiffening and CD8

Indexed as

CD8-Positive T-LymphocytesExtracellular MatrixLung NeoplasmsProtein-Lysine 6-OxidaseAnimalsHumansMiceMice, KnockoutMolecular Docking SimulationT-Cell ExhaustionYAP-Signaling ProteinsLOXL4 protein, humanProtein-Lysine 6-OxidaseYAP-Signaling Proteins

Identifiers

PMID42726857
PMCPMC13564810

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.