ArticleScience advances2026
Photoinduced cobalt-catalyzed enantioconvergent synthesis of 1,3-diamines via aziridine ring-opening addition.
Tingting Xia, Kejie Xu, Xiaochen Zhang, Xianqing Wu, Wei-Hong Zhu, Jingping Qu, Yifeng Chen
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In one paragraphArticle in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
Tingting XiaKey Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology and Dynamic Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology; Shanghai, 200237, China.ORCID 0009-0005-2401-1040 Kejie XuKey Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology and Dynamic Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology; Shanghai, 200237, China.
Xiaochen ZhangKey Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology and Dynamic Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology; Shanghai, 200237, China.
Xianqing WuKey Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology and Dynamic Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology; Shanghai, 200237, China.
Wei-Hong ZhuKey Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology and Dynamic Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology; Shanghai, 200237, China.ORCID 0000-0001-9103-166X Jingping QuKey Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology and Dynamic Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology; Shanghai, 200237, China.ORCID 0000-0002-7576-0798 Yifeng ChenKey Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, Frontiers Science Center for Materiobiology and Dynamic Chemistry, School of Chemistry and Molecular Engineering, East China University of Science and Technology; Shanghai, 200237, China.ORCID 0000-0003-3239-6209 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Chiral amines are privileged scaffolds with pervasive importance across the organic synthesis. Nevertheless, the stereoselective construction of 1,3-diamines bearing multiple stereocenters represents a significant and persistent challenge in synthetic chemistry. Addressing this, we recognized aziridines as ideal yet underutilized precursors. While these readily available three-membered heterocycles are established building blocks for chiral amines synthesis via ring-opening substitutions, catalytic methods that directly engage them in enantioselective addition to electrophiles have remained elusive. Herein, we report a photoinduced, cobalt-catalyzed enantioconvergent addition of styrenyl aziridines to imines via radical ring-opening. This strategy enables direct and modular access to valuable 1,3-diamine scaffolds bearing vicinal stereocenters-including a tetrasubstituted carbon chiral center-with excellent stereocontrol (99% ee, >20:1 dr). The reaction proceeds via a completely regioselective ring-opening pathway involving a stabilized benzylic radical intermediate, avoids waste generation from radical precursors, tolerates a broad range of substrates, and requires no stoichiometric metal reductants.
Identifiers
PMID42726854
PMCPMC13564919
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