Evidence map›Paper›PMID 42726853›Full record

ArticleScience advances2026

Widespread atypical UV-induced mutations form in single-stranded DNA.

Cameron Cordero, Brittany N Vandenberg, Isabelle Mittelstadt, Jordan Murch, Marian F Laughery, Piotr A Mieczkowski, John J Wyrick, Steven A Roberts

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Cameron CorderoDepartment of Microbiology and Molecular Genetics, University of Vermont, Burlington, VT 05405, USA.ORCID 0000-0001-8320-0953
Brittany N VandenbergDepartment of Microbiology and Molecular Genetics, University of Vermont, Burlington, VT 05405, USA.ORCID 0000-0003-2630-0100
Isabelle MittelstadtDepartment of Microbiology and Molecular Genetics, University of Vermont, Burlington, VT 05405, USA.ORCID 0009-0002-7283-8411
Jordan MurchDepartment of Microbiology and Molecular Genetics, University of Vermont, Burlington, VT 05405, USA.ORCID 0009-0003-1687-6357
Marian F LaugherySchool of Molecular Biosciences, Washington State University, Pullman, WA 99164, USA.
Piotr A MieczkowskiDepartment of Genetics, Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA.ORCID 0000-0003-2418-0096
John J WyrickSchool of Molecular Biosciences, Washington State University, Pullman, WA 99164, USA.ORCID 0000-0002-7911-3803
Steven A RobertsDepartment of Microbiology and Molecular Genetics, University of Vermont, Burlington, VT 05405, USA.ORCID 0000-0002-3628-5808

Funding

Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Deborah F. Tate · 1985 to 2026
$201.5M
Genome-wide analysis of the formation and mutagenesis of atypical UV photoproducts in skin cancerR01ES032814 · NIEHS · WASHINGTON STATE UNIVERSITY · PI STEVEN A ROBERTS, John J Wyrick · 2021 to 2026
$5.8M
NCI NIH HHS P30 CA016086NIEHS NIH HHS R01 ES032814
6 · The paper itself

Abstract

Persistence of common ultraviolet (UV)-induced lesions, like cyclobutane pyrimidine dimers (CPDs) and pyrimidine-pyrimidone (6-4) photoproducts (6-4-PPs), typically results in C>T substitutions at dipyrimidines: a mutation pattern that composes the single-base substitution (SBS) signature 7 in cancer. Oncogenic melanoma mutations rarely involve SBS7-like substitutions. We recently identified noncanonical UV-induced mutations in yeast that appear to originate from atypical AC and TA photoproducts. While an AC photoproduct could account for formation of BRAF V600K, other melanoma drivers like BRAF V600E and NRAS Q61K involve other mutation types, suggesting possible existence of additional atypical photoproducts. Here, we couple temperature-induced telomeric end resection in yeast with serial UV irradiation and whole-genome sequencing to show UV light induces an extended array of noncanonical mutations in single-stranded DNA (ssDNA). This includes A

Indexed as

DNA, Single-StrandedMutationUltraviolet RaysDNA DamageDNA RepairExcision RepairHumansPyrimidine DimersSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsTelomereDNA, Single-StrandedPyrimidine DimersSaccharomyces cerevisiae Proteins

Identifiers

PMID42726853
PMCPMC13564860

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.