Evidence map›Paper›PMID 42726653›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Direct activation of SARM1 by dsDNA is not supported by biochemical and cellular evidence.

Allison H Kao, Biswa P Mishra, Mitchell Sorbello, Wenbin Zhang, Qinyi Zhou, Yuefeng Jiang, Veronika Masic, Paige Harten, Weixi Gu, Jian Yuan Yang and 10 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Direct activation of SARM1 by dsDNA is not supported by biochemical and cellular evidence.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Allison H Kao *Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110.
Biswa P Mishra *Institute for Biomedicine and Glycomics, Griffith University, Gold Coast, QLD 4222, Australia.ORCID 0000-0001-7069-3138
Mitchell Sorbello *School of Chemistry and Molecular Biosciences, Institute for Molecular Bioscience and Australian Infectious Diseases Research Centre, University of Queensland, Brisbane, QLD 4072, Australia.
Wenbin Zhang *National Institute of Biological Sciences, Beijing 102206, China.
Qinyi ZhouNational Institute of Biological Sciences, Beijing 102206, China.
Yuefeng JiangState Key Laboratory of Natural and Biomimetic Drugs, Department of Molecular and Cellular Pharmacology, Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.
Veronika MasicInstitute for Biomedicine and Glycomics, Griffith University, Gold Coast, QLD 4222, Australia.
Paige HartenInstitute for Biomedicine and Glycomics, Griffith University, Gold Coast, QLD 4222, Australia.
Weixi GuSchool of Chemistry and Molecular Biosciences, Institute for Molecular Bioscience and Australian Infectious Diseases Research Centre, University of Queensland, Brisbane, QLD 4072, Australia.
Jian Yuan YangDivision of Biomedical Health Sciences, School of Medicine, The Chinese University of Hong Kong, Shenzhen 518172, China.
A Joseph BloomDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110.
Robi D MitraDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0002-2680-4264
Zhe ZhangState Key Laboratory of Natural and Biomimetic Drugs, Department of Molecular and Cellular Pharmacology, Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, School of Pharmaceutical Sciences, Peking University, Beijing 100191, China.ORCID 0000-0002-4932-4343
Yong Juan ZhaoDivision of Biomedical Health Sciences, School of Medicine, The Chinese University of Hong Kong, Shenzhen 518172, China.ORCID 0000-0003-4564-1912
Giuseppe OrsomandoDepartment of Clinical Sciences, Section of Biochemistry, Polytechnic University of Marche, Ancona 60131, Italy.
Xiaodong WangNational Institute of Biological Sciences, Beijing 102206, China.ORCID 0000-0001-9885-356X
Jeffrey MilbrandtDepartment of Genetics, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0002-5477-7689
Bostjan KobeSchool of Chemistry and Molecular Biosciences, Institute for Molecular Bioscience and Australian Infectious Diseases Research Centre, University of Queensland, Brisbane, QLD 4072, Australia.ORCID 0000-0001-9413-9166
Thomas VeInstitute for Biomedicine and Glycomics, Griffith University, Gold Coast, QLD 4222, Australia.
Aaron DiAntonioDepartment of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110.ORCID 0000-0002-7262-0968

Funding

DISSECTION OF SARM1-INDUCED AXON DEGENERATION AND CELL DEATHR01NS087632 · NINDS · WASHINGTON UNIVERSITY · PI Aaron Diantonio, JEFFREY D MILBRANDT · 2014 to 2026
$6.4M
Regulation of axonal degeneration by the DLK kinaseR37NS065053 · NINDS · WASHINGTON UNIVERSITY · PI Aaron Diantonio · 2020 to 2026
$4.3M
REGULATION OF AXONAL DEGENERATION BY THE DLK KINASER01NS065053 · NINDS · WASHINGTON UNIVERSITY · PI DIANTONIO, AARON · 2010 to 2019
$3.3M
DHAC | National Health and Medical Research Council (NHMRC) 1196590 and 2042089 and 2025931HHS | National Institutes of Health (NIH) NS087632Ministry of Science and Technology of the People's Republic of China (MOST) InsititutionalMOST | National Natural Science Foundation of China (NSFC) 32470755 to Y.J.Z.; 32471252| Natural Science Foundation of Beijing Municipality () InstitutionalNINDS NIH HHS R01 NS065053NINDS NIH HHS R01 NS087632NINDS NIH HHS R37 NS065053
6 · The paper itself

Abstract

Sterile alpha and Toll/interleukin-1 receptor motif-containing protein 1 (SARM1) is a NAD

Indexed as

Armadillo Domain ProteinsCytoskeletal ProteinsDNAAnimalsHumansMiceNADNeuronsArmadillo Domain ProteinsCytoskeletal ProteinsDNANADSARM1 protein, humanSARM1 protein, mouseaxon degenerationDNANADaseneurodegenerationSARM1

Identifiers

PMID42726653
PMCPMC13578336

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.