Evidence map›Paper›PMID 42726576›Full record

ArticleNanomaterials (Basel, Switzerland)2026

Dual-Targeted Inhibition of PAR

Marcella de A Ferreira, Paz Duran, Raquel Tonello, Veronica Emad Farag, Mae Stabile D'Ambra, Evan Yuhan Chen, Sher B Poudel, Kam W Leong, Dane D Jensen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Marcella de A FerreiraPain Research Center, College of Dentistry, New York University, New York, NY 10010, USA.
Paz DuranPain Research Center, College of Dentistry, New York University, New York, NY 10010, USA.ORCID 0000-0001-8729-8636
Raquel TonelloPain Research Center, College of Dentistry, New York University, New York, NY 10010, USA.ORCID 0000-0002-2175-9804
Veronica Emad FaragDepartment of Biomedical Engineering, Columbia University, New York, NY 10027, USA.
Mae Stabile D'AmbraDepartment of Molecular Pathobiology, College of Dentistry, New York University, New York, NY 10010, USA.
Evan Yuhan ChenPain Research Center, College of Dentistry, New York University, New York, NY 10010, USA.ORCID 0009-0009-9998-7776
Sher B PoudelDepartment of Molecular Pathobiology, College of Dentistry, New York University, New York, NY 10010, USA.ORCID 0000-0003-3733-4648
Kam W LeongDepartment of Biomedical Engineering, Columbia University, New York, NY 10027, USA.
Dane D JensenPain Research Center, College of Dentistry, New York University, New York, NY 10010, USA.ORCID 0000-0001-6540-2375

Funding

Mechanisms of Endosomal Signaling of ItchR01NS125413 · NINDS · NEW YORK UNIVERSITY · PI Dane D Jensen · 2022 to 2026
$1.9M
NINDS NIH HHS R01 NS125413NINDS NIH HHS R01NS125413
6 · The paper itself

Abstract

Osteoarthritis (OA) is the most prevalent chronic joint disease characterized by the progressive degeneration of articular cartilage leading to debilitating locomotor restrictions and persistent pain. The pathogenesis of OA is driven by a complex cycle of inflammatory mediators, where G protein-coupled receptor protease-activated receptor 2 (PAR

Indexed as

endosomal signalingnanoparticleosteoarthritispainPAR2

Identifiers

PMID42726576
PMCPMC13567674

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.