Evidence map›Paper›PMID 42726466›Full record

ReviewFASEB journal : official publication of the Federation of American Societies for Experimental Biology2026

Insights Into Spatial Transcriptomics: Exploring Recent Technical Developments and Their Diverse Applications.

Xianghui Li, Zewei Yang, Jingjing Li, Huiru Cao, Ke Xu, Jiawen Shen, Yange Wang, Salwa E Gomaa, Ge Cheng, Tieshan Teng and 3 more

Abstract readReview
In one paragraph

Review in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xianghui LiDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Henan University, Kaifeng, China.
Zewei YangDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Henan University, Kaifeng, China.
Jingjing LiDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Henan University, Kaifeng, China.ORCID https://orcid.org/0009-0008-1045-0810
Huiru CaoDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Henan University, Kaifeng, China.
Ke XuDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Henan University, Kaifeng, China.
Jiawen ShenDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Henan University, Kaifeng, China.
Yange WangDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Henan University, Kaifeng, China.
Salwa E GomaaDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Henan University, Kaifeng, China.
Ge ChengDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Henan University, Kaifeng, China.
Tieshan TengDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Henan University, Kaifeng, China.
Jicheng LiDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Henan University, Kaifeng, China.
Xiaoqing WangDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Henan University, Kaifeng, China.ORCID https://orcid.org/0009-0003-5437-0779
Xiaotao DongDepartment of Physiology and Pathophysiology, School of Basic Medical Sciences, Henan University, Kaifeng, China.

Funding

Kaifeng Key Science and Technology Project 262102310199Kaifeng Key Science and Technology Project 262102311032Kaifeng Key Science and Technology Project 262102311177Key R&D and Promotion Projects of Henan Province 2053168National Natural Science Foundation of China (NSFC) 82401779
6 · The paper itself

Abstract

Spatial transcriptomics (ST) integrates spatial information with gene expression data to quantify mRNA levels across diverse genes within the structural context of tissues and cells. This field enables simultaneous capture of cellular gene expression at the transcriptomic level while preserving spatial localization information. This approach enhances our understanding of cellular interactions and their immediate microenvironments. Utilizing this technique, researchers can gain deep insights into biological development and disease mechanisms across different tissue regions. Recently, ST has witnessed substantial advancements; however, it faces challenges such as reliance on specific sample types, the resolution of visualized genes, commercial feasibility, and the capability to collect comprehensive single-cell data. This article summarizes four primary ST techniques, comparing and analyzing diverse research methodologies to improve experimental design and analytical evaluation. It highlights the essential role of ST in integrated multi-omics analyses and the development of disease models while contemplating its future advancements.

Indexed as

Gene Expression ProfilingSpatial TranscriptomicsTranscriptomeAnimalsHumansMultiomicsSingle-Cell AnalysisSingle-Cell Gene Expression Analysismulti‐omicsomics technologysingle‐cell resolutionspatial positionspatial transcriptomics

Identifiers

PMID42726466
PMCPMC13565288

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.