Evidence map›Paper›PMID 42726465›Full record

ArticleProbiotics and antimicrobial proteins2026

Safety Assessment on Probiotic Mixture "Prohep" and Longitudinal Evaluation on its Gut Microbial Modulation Ability in Mice.

Fangfei Zhang, Koei Ho Lam Cheung, Emily Kwun Kwan Lo, Congjia Chen, Jetty Chung-Yung Lee, Felicianna, Marsena Jasiel Ismaiah, Hoi Kit Matthew Leung, Hani El-Nezami

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Article in Probiotics and antimicrobial proteins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Fangfei ZhangSchool of Biological Sciences, University of Hong Kong, Pokfulam, Hong Kong S.A.R, 000, China.
Koei Ho Lam CheungLi Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong S.A.R., 000, China.
Emily Kwun Kwan LoSchool of Biological Sciences, University of Hong Kong, Pokfulam, Hong Kong S.A.R, 000, China.ORCID http://orcid.org/0000-0001-9258-0716
Congjia ChenSchool of Biological Sciences, University of Hong Kong, Pokfulam, Hong Kong S.A.R, 000, China.
Jetty Chung-Yung LeeSchool of Biological Sciences, University of Hong Kong, Pokfulam, Hong Kong S.A.R, 000, China.ORCID http://orcid.org/0000-0002-8175-7069
FeliciannaSchool of Biological Sciences, University of Hong Kong, Pokfulam, Hong Kong S.A.R, 000, China.ORCID http://orcid.org/0000-0003-1252-5667
Marsena Jasiel IsmaiahSchool of Biological Sciences, University of Hong Kong, Pokfulam, Hong Kong S.A.R, 000, China.
Hoi Kit Matthew LeungSchool of Biological Sciences, University of Hong Kong, Pokfulam, Hong Kong S.A.R, 000, China.
Hani El-NezamiSchool of Biological Sciences, University of Hong Kong, Pokfulam, Hong Kong S.A.R, 000, China. elnezami@hku.hk.ORCID http://orcid.org/0000-0001-6700-4346

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The probiotic mixture Prohep has been studied as a potential therapy for liver diseases such as MASLD, MASH, and HCC. To evaluate its safety, we conducted an experiment on CD-1 mice to assess its acute, subacute, and subchronic oral toxicity. The results showed that Prohep intake did not cause any morbidity or mortality, nor did it produce adverse changes in body weight, histopathological, haematological, or biochemical parameters. Therefore, Prohep is considered safe for consumption, with LD

Identifiers

PMID42726465

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.