ArticleTissue engineering and regenerative medicine2026
Vectors Trgeting Hepatocyte: Reconstructive Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes.
Article in Tissue engineering and regenerative medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundSpecific binding of the hepatitis B virus (HBV) pre-S1 protein to Na
methodsUmbilical cord mesenchymal stem cell (UC-MSC)-derived exosomes were isolated and characterized. The gene sequence encoding the CD90 C-terminal signal peptide was fused with the pre-S1 gene and cloned into a lentiviral vector (VP045-U6-PGK-preS1-CD90-hygro), enabling membrane anchoring of pre-S1 on UC-MSC-derived exosomes. PKH26 probe, Phalloidin-AF488 probe, and DiR dye were used to explore the targeting of reconstituted UC-MSC-derived exosomes on hepatocytes and liver.
resultsIsolated UC-MSCs exhibited fibroblast-like morphology and retained the capacity to differentiate into osteoblasts, adipocytes, and chondrocyte. The immunophenotype of UC-MSCs was characterized as CD34
conclusionUC-MSC-derived exosomes expressing pre-S1 exhibit specific tropism for hepatocytes and liver tissue. These engineered exosomes represent a promising delivery platform for therapeutic drugs and nucleic acid cargos in HBV-targeted therapy.
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