Evidence map›Paper›PMID 42726448›Full record

ArticleThe international journal of cardiovascular imaging2026

Quantitative coronary artery and aortic valve calcification by virtual non-contrast Images from dual-energy delayed CT scans in patients with severe aortic stenosis.

Hidesato Fujito, Kaveh Rezaei Bookani, Bashaer Gheyath, Sunam Lee, Sung Woo Cho, Balaji Tamarappoo, Alan C Kwan, Raj Makkar, Damini Dey, Piotr Slomka and 3 more

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Article in The international journal of cardiovascular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Hidesato FujitoDepartment of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Kaveh Rezaei BookaniDepartment of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Bashaer GheyathDepartment of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Sunam LeeDepartment of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Sung Woo ChoDepartment of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Balaji TamarappooDepartment of Cardiology, University of Arizona School of Medicine, Phoenix, AZ, USA.
Alan C KwanDepartment of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Raj MakkarDepartment of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Damini DeyDepartment of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, USA.
Piotr SlomkaDepartment of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, USA.
Daniel S BermanDepartment of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
John FriedmanDepartment of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Donghee HanDepartment of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA. donghee.han@cshs.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

With the growing use of delayed dual-energy computed tomography (DECT) imaging for extracellular volume assessment, this study aimed to assess the accuracy of coronary artery calcium (CAC) and aortic valve calcification (AVC) quantification in virtual non-contrast (VNC) images derived from delayed DECT images. Eighty-eight patients undergoing pre-transcatheter aortic valve replacement (TAVR) cardiac CTA with DECT were retrospectively enrolled. We compared CAC score (CACS), CAC volume, AVC score (AVCS), and AVC volume between true non-contrast (TNC) and VNC images. VNC images were created by subtracting iodine from delayed CT angiography using commercial post-processing software. Concordance for the likelihood of severe aortic stenosis (AS) between TNC and VNC was assessed using guideline-based AVCS thresholds: men > 3,000 AU, women > 1,600 AU (highly likely); men > 2,000 AU, women > 1,200 AU (likely). CACS was lower in VNC than TNC (363.0 [13.7-1,154.0] AU vs. 470.1 [46.8-1,569.9] AU, p < 0.001), but the correlation was excellent (r = 0.966). No significant difference between VNC and TNC was observed in AVCS (959.5 [321.2-2,475.0] AU vs. 1,079.6 [492.2-2,329.4] AU, p = 0.521), with strong correlation (r = 0.966). Application of a correction factor (1.1-fold) improved agreement between VNC- and TNC-derived CACS (weighted κ = 0.839 to 0.869). Diagnostic concordance for severe AS between VNC and TNC was 92.1% (weighted kappa = 0.785) at the "highly likely" threshold and 97.7% (weighted kappa = 0.952) at the "likely" threshold. Delayed VNC images from DECT demonstrate strong agreement with TNC images for CACS and AVCS, suggesting that delayed VNC could potentially reduce the need for TNC acquisition in pre-TAVR assessment.

Indexed as

Aortic stenosisAortic valve calcificationCoronary artery calciumDual energy computed tomographytranscatheter valve intervention

Identifiers

PMID42726448

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.