Evidence map›Paper›PMID 42726436›Full record

ArticleInflammopharmacology2026

Anti-inflammatory approach of Polypodium vulgare roots by downregulation of pro-inflammatory cytokines in complete Freund's adjuvant-induced arthritis rats.

Farah Zafar, Ghazala Shaheen, Shafia Arshad, Faiza Irshad, Muhammad Omer Iqbal, Wajid Syed, Mohamed N A Al Arifi, Naji Alqahtan

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Article in Inflammopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Farah ZafarDepartment of Eastern Medicine, University College of Conventional Medicine, Faculty of Medicine and Allied Health Sciences, The Islamia University of Bahawalpur, Bahawalpur, 63100, Pakistan. dr.farahzafar@gmail.com.ORCID http://orcid.org/0000-0003-1328-4623
Ghazala ShaheenDepartment of Eastern Medicine, University College of Conventional Medicine, Faculty of Medicine and Allied Health Sciences, The Islamia University of Bahawalpur, Bahawalpur, 63100, Pakistan.
Shafia ArshadDepartment of Eastern Medicine, University College of Conventional Medicine, Faculty of Medicine and Allied Health Sciences, The Islamia University of Bahawalpur, Bahawalpur, 63100, Pakistan.
Faiza IrshadDepartment of Eastern Medicine, University College of Conventional Medicine, Faculty of Medicine and Allied Health Sciences, The Islamia University of Bahawalpur, Bahawalpur, 63100, Pakistan.
Muhammad Omer IqbalKey Laboratory of Marine Drugs, The Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, 266003, China.
Wajid SyedDepartment of Clinical Pharmacy, College of Pharmacy, King Saud University, 11451, Riyadh, Saudi Arabia.
Mohamed N A Al ArifiDepartment of Clinical Pharmacy, College of Pharmacy, King Saud University, 11451, Riyadh, Saudi Arabia.
Naji AlqahtanDepartment of Nursing Administration and Education, College of Nursing, King Saud University, 11451, Riyadh, Saudi Arabia.

Funding

King Saud University ORF-2025-81
6 · The paper itself

Abstract

backgroundPolypodium vulgare Linn, roots commonly used in traditional Unani medicine, has been employed to treat ailments. Despite its extensive traditional use, particularly for inflammatory conditions like arthritis, has not been fully explored. AIM OF STUDY: The study aimed to evaluate the anti-inflammatory and anti-lipoxygenase effects of a 70% ethanolic extract of Polypodium. vulgare (P. vulgare) (HEPV) roots in a complete Freund's adjuvant (CFA)-induced arthritis rat model. MATERIALS AND

methodsPhytochemical presence was confirmed through preliminary analysis and GC-MS. Various assays, including 2,2-Diphenyl-1-Picrylhydrazyl (DPPH) antioxidant potential, lipoxygenase inhibition, Human red blood cells membrane stabilization, and protein denaturation, were conducted. The anti-arthritic effects were evaluated in Wistar albino rats using a CFA-induced arthritis model, alongside its impact on blood parameters and pro-inflammatory cytokine mRNA expression (TNF-α and IL-6) through qRT-PCR.

resultsHEPV demonstrated antioxidant effect accompanied by an 50% inhibitory concentration (IC

conclusionThe study provides a preclinical basis for the anti-inflammatory and anti-arthritic potential of P. vulgare, warranting further toxicological and pharmacokinetic studies to confirm its therapeutic benefits in human.

Indexed as

ArthritisComplete Freund’s adjuvant (CFA)CytokinesHistopathologyInflammationPolypodium vulgare Linn

Identifiers

PMID42726436

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