ArticleJournal of gastrointestinal cancer2026
Association of Cachexia-Related Status With Treatment Outcomes in Advanced Gastric Cancer Receiving First-Line Therapy With or Without Nivolumab.
Article in Journal of gastrointestinal cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Correspondence: Cachexia-Related Status in Advanced Gastric Cancer: Marker of Progression or Driver of Prognosis?Journal of gastrointestinal cancer · 2026Article
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe clinical significance of longitudinal cachexia-related status during first-line therapy for advanced gastric cancer remains unclear in the era of nivolumab-containing chemotherapy. We evaluated its association with outcomes according to nivolumab use.
methodsWe retrospectively analyzed 121 patients with HER2-negative unresectable advanced or recurrent gastric cancer who received first-line oxaliplatin- plus fluoropyrimidine-based chemotherapy between 2017 and 2024. Modified Glasgow Prognostic Score (mGPS) 2 status and modified European Palliative Care Research Collaborative (EPCRC)-defined cachexia status were assessed as time-dependent covariates. Progression-free survival (PFS) and overall survival (OS) were analyzed using time-dependent Cox proportional hazards models.
resultsThe cohort included 69 patients in the non-nivolumab group and 52 in the nivolumab-containing group. Median age was 71 years, 76 patients (63%) were male, and baseline mGPS 2 was present in 37 patients (31%). The cumulative proportion of patients who met the mGPS 2 criterion by 6 months was 55% in the non-nivolumab group and 57% in the nivolumab-containing group. Time-dependent mGPS 2 status was not significantly associated with PFS (hazard ratio [HR], 1.49; 95% confidence interval [CI], 0.69-3.20; P = 0.30), but was associated with shorter OS (HR, 2.17; 95% CI, 1.15-4.10; P = 0.017). No statistically significant interaction between time-dependent mGPS 2 status and nivolumab use was observed for PFS or OS. Time-dependent modified EPCRC-defined cachexia status was not significantly associated with PFS or OS.
conclusionsTime-dependent mGPS 2 status during first-line therapy was associated with shorter OS, but not PFS.
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