Evidence map›Paper›PMID 42726365›Full record

ReviewCurrent pain and headache reports2026

The Evolving Role of Peripheral Nerve Stimulation in Postoperative Analgesia and Recovery.

Alaa Abd-Elsayed, Marco P Troka, Salma H Gadelhak, Mofe Ajenifuja, Robert Moghim, Alan D Kaye, Madelyn J Reilly

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current pain and headache reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Alaa Abd-ElsayedDepartment of Anesthesiology, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, B6/319 CSC, Madison, WI, 53792-3272, USA. alaaawny@hotmail.com.ORCID http://orcid.org/0000-0002-9890-7860
Marco P TrokaDepartment of Anesthesiology, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, B6/319 CSC, Madison, WI, 53792-3272, USA.ORCID http://orcid.org/0009-0000-9305-9439
Salma H GadelhakDepartment of Anesthesiology, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, B6/319 CSC, Madison, WI, 53792-3272, USA.
Mofe AjenifujaDepartment of Anesthesiology, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, B6/319 CSC, Madison, WI, 53792-3272, USA.
Robert MoghimInterventional Pain and Spine, Colorado Pain Care, 2696 S Colorado Blvd #240, Denver, CO, 80222, USA.
Alan D KayeDepartment of Anesthesiology, Louisiana State University School of Medicine, Shreveport, LA, 71103, USA.ORCID http://orcid.org/0000-0003-2464-0187
Madelyn J ReillyDepartment of Anesthesiology, University of Wisconsin School of Medicine and Public Health, 600 Highland Avenue, B6/319 CSC, Madison, WI, 53792-3272, USA.ORCID http://orcid.org/0009-0005-8828-7740

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purpose of reviewAcute postoperative pain has traditionally been managed with opioids and regional nerve blocks, both of which are associated with limitations including drug-related adverse effects and motor blockade. This narrative review evaluates temporary percutaneous peripheral nerve stimulation (PNS) as an advanced, opioid- and motor-sparing neuromodulation strategy for postoperative pain management. RECENT

findingsTemporary PNS selectively targets sensory afferent fibers to provide immediate nociceptive inhibition while promoting neuroplastic changes that reverse central sensitization, resulting in sustained analgesia beyond device removal. Unlike regional anesthesia, temporary PNS preserves motor function, facilitating early mobilization and rehabilitation. Clinical evidence across multiple surgical specialties demonstrates that 14- to 60-day temporary PNS significantly reduces postoperative pain scores and cumulative opioid consumption while maintaining a favorable safety profile, with adverse events primarily limited to mild insertion-site reactions. Temporary percutaneous PNS represents an important advancement in postoperative pain management by providing targeted analgesia without motor impairment or opioid-related adverse effects. Its ability to support Enhanced Recovery After Surgery (ERAS) pathways while potentially reducing the risk of persistent postsurgical pain highlights its growing clinical value. Further studies are needed to optimize stimulation parameters, refine patient selection, and determine its long-term role in preventing the transition from acute to chronic postsurgical pain.

Indexed as

AnalgesiaPain ManagementPeripheral NervesPostoperative PainTranscutaneous Electric Nerve StimulationAnalgesics, OpioidHumansAnalgesics, OpioidAcute pain managementEnhanced recovery after surgeryERASNeuromodulationNeuroplasticityOpioid sparing analgesiaPeripheral nerve stimulationPNSPostoperative pain

Identifiers

PMID42726365

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.