ArticleBrain imaging and behavior2026
Eight-year longitudinal changes in functional connectivity of the fatigue network in Parkinson's disease: evidence from four timepoints.
Article in Brain imaging and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
Fatigue is a prevalent non-motor symptom in Parkinson's disease (PD), yet its long-term neural substrates remain poorly understood. The aim of this study was to characterize eight-year, four-timepoint longitudinal changes in the fatigue-related brain functional connectivity (FC) in PD and examine their associations with fatigue severity. Fifty-one PD patients and 37 healthy controls (HC) were recruited. All variables were assessed at four timepoints: baseline (year-1), year-3, year-5, and year-8. Region of interest (ROI)-to-ROI analyses targeted a predefined fatigue-related network. A visual network served as a control system. Longitudinal FC effects were assessed using a 2 × 4 ANCOVA (group×time), adjusting for age, sex, and Levodopa Equivalent Daily dose. Fatigue severity was measured with the Fatigue Severity Scale. PD patients exhibited a significant progressive reduction in FC between the right dorsolateral prefrontal cortex (DLPFC) and left dorsal anterior cingulate cortex (dACC) compared with HC. Results remained significant also including depression and global cognition as covariates. Within PD, lower right DLPFC-left dACC FC was associated with higher fatigue, whereas no associations were observed in HC. The fatigue network was specifically associated with fatigue scores, but not with depression or cognition; no longitudinal or fatigue-related effects were found in the visual control network. Across eight years and four assessments, PD is characterized by a gradual disruption of prefrontal-cingulate connectivity within a key fatigue-related hub. This evolving DLPFC-dACC decoupling is linked to worsening fatigue and is specific to the fatigue network, providing preliminary evidence for a neural marker and therapeutic target for fatigue progression in PD.
Indexed as
Identifiers
42726348What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.