Evidence map›Paper›PMID 42726329›Full record

ArticleJournal of computer-aided molecular design2026

Design, synthesis and multitarget evaluation of cyclopropyl-appended thiohydantoin derivatives as dual cholinesterase and COX inhibitors with antioxidant activity: a combined experimental and computational study.

Amina Hussain, Rafaqat Hussain, Hina Sarfraz, Uzma Azam, Muhammad Hasnat, Shoaib Khan, Sibghat Mansoor Rana, Yazeed M Asiri, Zainab

Abstract read
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Article in Journal of computer-aided molecular design, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Amina HussainDepartment of Biochemistry, University of Agriculture, Faisalabad, Pakistan.
Rafaqat HussainCollege of Biology, Hunan University Changsha, Changsha, 410082, Hunan, China. rafaqathussain0347@hnu.edu.cn.
Hina SarfrazDepartment of Chemistry, Quaid-I-Azam University, Islamabad, 45320, Pakistan.
Uzma AzamDepartment of Chemistry, Quaid-I-Azam University, Islamabad, 45320, Pakistan.
Muhammad HasnatInstitute of Pharmaceutical Sciences (IPS), University of Veterinary and Animal Sciences (UVAS), Lahore, Pakistan.
Shoaib KhanDepartment of Chemistry, Abbottabad University of Science and Technology, Abbottabad, 22500, Pakistan.
Sibghat Mansoor RanaCollege of Pharmacy, University of the Punjab, Lahore, Pakistan.
Yazeed M AsiriDepartment of Chemistry, College of Science, Taif University, P.O. Box 11099, 21944, Taif, Saudi Arabia.
ZainabDepartment of Chemistry, Hazara University, Mansehra, 21120, Khyber Pakhtunkhwa, Pakistan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The complex pathology of Alzheimer's disease (AD), together with the limited effectiveness of current treatments, has sparked the search for multifunctional agents capable of targeting key pathological mechanisms simultaneously. In this study, a novel series of cyclopropyl-appended thiohydantoin derivatives 4a-d and their corresponding S-substituted analogues 6a-d were rationally designed and synthesized as multi-target agents. Following complete spectroscopic characterization (

Indexed as

AntioxidantsCholinesterase InhibitorsCyclooxygenase 2 InhibitorsCyclooxygenase InhibitorsAcetylcholinesteraseAlzheimer DiseaseCyclooxygenase 2Drug DesignHumansMolecular Docking SimulationStructure-Activity RelationshipAcetylcholinesteraseAntioxidantsCholinesterase InhibitorsCyclooxygenase 2Cyclooxygenase 2 InhibitorsCyclooxygenase InhibitorsAlzheimer diseaseCholinesteraseCOX-2CyclopropylMolecular dockingStructure activity relationshipsThiohydantoin derivatives

Identifiers

PMID42726329

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.