Evidence map›Paper›PMID 42726295›Full record

ArticleCalcified tissue international2026

Potential Role for the Ubiquitin Ligase SIAH2 in Modulating Bone Morphology and Adiposity.

Matthew C Scott, Bhaswati Ghosh, Gail Kilroy, Beata Lecka-Czernik, Z Elizabeth Floyd

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Calcified tissue international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Matthew C ScottPennington Biomedical Research Center, Baton Rouge, LA, 70808, USA.ORCID http://orcid.org/0000-0002-6741-3526
Bhaswati GhoshPennington Biomedical Research Center, Baton Rouge, LA, 70808, USA.ORCID http://orcid.org/0009-0009-4124-8452
Gail KilroyPennington Biomedical Research Center, Baton Rouge, LA, 70808, USA.
Beata Lecka-CzernikThe University of Toledo, OH, 43606, Toledo, USA.ORCID http://orcid.org/0000-0002-1216-9634
Z Elizabeth FloydPennington Biomedical Research Center, Baton Rouge, LA, 70808, USA. Elizabeth.Floyd@pbrc.edu.ORCID http://orcid.org/0000-0002-3002-6186

Funding

Training in Botanical Approaches to Combat Metabolic SyndromeT32AT004094 · NCCIH · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI BRANTLEY, PHILLIP J, STEPHENS, JACQUELINE M · 2009 to 2024
$5.7M
PPARG regulates osteocyte bioenergetics and function during agingR01AG071332 · NIA · UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS · PI GRIFFIN, PATRICK ROBERT, LECKA-CZERNIK, BEATA ANNA · 2021 to 2025
$3.4M
Regulation of Insulin Sensitivity by the Ubiquitin Ligase Siah2R01DK099625 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI FLOYD, ZELPHA ELIZABETH · 2014 to 2017
$1.2M
Regulation of PPARgamma in Adipocytes by Siah2R56DK089020 · NIDDK · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI FLOYD, ZELPHA ELIZABETH · 2010 to 2011
$442k
American Diabetes Association 1-19-IBS-029NCCIH NIH HHS T32 AT004094NIA NIH HHS R01 AG071332NIA NIH HHS RO1AG071332NIDDK NIH HHS 1RO1DK099625NIDDK NIH HHS 5R56DK89020NIDDK NIH HHS R01 DK099625NIDDK NIH HHS R56 DK089020
6 · The paper itself

Abstract

Marrow adipose expansion, with obesity or ageing, increases fracture risk. Skeletal stem cells can commit to osteoblast or adipocyte endpoints, an inverse relationship influenced by peroxisome proliferator-activated receptor gamma (PPARγ). Seven in absentia homologue 2 (SIAH2) is a ubiquitin ligase that acts in peripheral adipose tissue stromal progenitors, promoting PPARγ activity and adipogenesis. The pivotal role of PPARγ in bone marrow adipose tissue accumulation prompted us to evaluate SIAH2's role in the balance between osteogenesis and adipogenesis. Using adherent skeletal stem and/or progenitor cells (SSPCs) isolated from the marrow of wild-type (WT) and Siah2

Indexed as

AdiposityBone and BonesNuclear ProteinsOsteogenesisUbiquitin-Protein LigasesAdipogenesisAdipose TissueAnimalsCell DifferentiationMaleMiceMice, Inbred C57BLMice, KnockoutPPAR gammaSeven in Absentia ProteinsStem CellsNuclear ProteinsPPAR gammaSeven in Absentia ProteinsSiah2 protein, mouseUbiquitin-Protein LigasesAdipogenesisOsteogenesisPPARγSeven in absentia homolog 2Skeletal progenitor cellsSkeletal stem and/or progenitor cellsSkeletal stem cellsTrabecular bone

Identifiers

PMID42726295
PMCPMC13569602

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.