Evidence map›Paper›PMID 42726266›Full record

ArticleOrganic letters2026

Cyanamide-Induced Desulfhydration Enables Access to α,β-Dehydropeptides.

Yi Yang, Songyi Xue, Ryan Moreira, Wilfred A van der Donk

Abstract read
In one paragraph

Article in Organic letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yi YangDepartment of Chemistry and Howard Hughes Medical Institute, University of Illinois at Urbana-Champaign, Urbana, Illinois61822, United States.ORCID 0009-0009-7467-0641
Songyi XueDepartment of Chemistry and Howard Hughes Medical Institute, University of Illinois at Urbana-Champaign, Urbana, Illinois61822, United States.ORCID 0009-0005-0684-8832
Ryan MoreiraDepartment of Chemistry and Howard Hughes Medical Institute, University of Illinois at Urbana-Champaign, Urbana, Illinois61822, United States.ORCID 0000-0003-0694-219X
Wilfred A van der DonkDepartment of Chemistry and Howard Hughes Medical Institute, University of Illinois at Urbana-Champaign, Urbana, Illinois61822, United States.ORCID 0000-0002-5467-7071

Funding

Howard Hughes Medical InstituteHoward Hughes Medical Institute NALife Sciences Research Foundation NASchool of Molecular and Cellular Biology, College of Liberal Arts and Sciences, University of Illinois Urbana-Champaign NA
6 · The paper itself

Abstract

Dehydroamino acids are found in natural products, disease-associated proteins, and are used for the diversification of proteins and peptides. The synthesis of peptide sequences containing dehydroamino acids remains nontrivial and only a few chemical methods allow for their incorporation. We report the conversion of amino acid residues bearing β-thiols into dehydroamino acids through the treatment of unprotected peptides and proteins with cyanamide under mild, fully aqueous conditions that are compatible with commonly used buffer salts.

Indexed as

Amino AcidsCyanamidePeptidesMolecular StructureSulfhydryl CompoundsAmino AcidsCyanamidePeptidesSulfhydryl Compounds

Identifiers

PMID42726266
PMCPMC13573842

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.