ArticleNaunyn-Schmiedeberg's archives of pharmacology2026
ZhuJing Pill retards lens-induced myopia progression by improving ciliary muscle mitochondrial function via KEAP1/NRF2-TGF-β axis.
Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
To evaluate the anti-myopic effect of ZhuJing Pill (ZJP) in a guinea pig model of lens-induced myopia (LIM) and investigate whether ZJP attenuates ciliary muscle fibrosis by improving mitochondrial function, regulating KEAP1/NRF2 antioxidant defense, and inhibiting TGF-β-related fibrotic signaling. One hundred and forty-four male guinea pigs (2 weeks old) were randomly assigned to four groups: a normal control (NC), a LIM model, a ZJP treatment, and a sham (SHAM). All but NC wore - 6.00 D lenses on the right eye to induce myopia. ZJP was orally administered at 5.0 g/kg/day for 4 or 6 weeks. Refractive error, axial length, and ciliary muscle structure were measured by A-scan ultrasonography and OCT. Ciliary muscle tissues were analyzed using HE, Masson's trichrome, and Sirius Red staining. Mitochondrial membrane potential, Ca
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