Evidence map›Paper›PMID 42726166›Full record

ArticleMolecular biology reports2026

Dysregulation of the TLR4/MYD88 Signaling Pathway in Egyptian Females with Breast Cancer: Implications for Tumor Progression.

Sulaiman Mohammed Alshaban, Tawfik Elkhadrary, Walid Elnahhas, Amira Awadalla, Omali Y El-Khawaga

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sulaiman Mohammed AlshabanFaculty of Science, Chemistry Department, Biochemistry Division, Mansoura University, Mansoura, 35516, Egypt. s.alshaban@hotmail.com.
Tawfik ElkhadraryDepartment of Medical Oncology, Oncology Center (OCMU), Mansoura University, Mansoura, 35516, Egypt.
Walid ElnahhasDepartment of Surgical Oncology, Oncology Center (OCMU), Mansoura University, Mansoura, 35516, Egypt.
Amira AwadallaFellow of Genetics and Molecular Biology, Oncology Center (OCMU), Mansoura University, Mansoura, 35516, Egypt.
Omali Y El-KhawagaFaculty of Science, Chemistry Department, Biochemistry Division, Mansoura University, Mansoura, 35516, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBreast cancer (BC) is a serious health issue, representing one of the most frequently occurring cancers among women. BC treatment and prevention are challenging due to its complex pathophysiology and variety of clinical signs. Therefore, we aimed to study the role of the TLR4/MYD88 signaling pathway in BC. SUBJECTS AND

methodsThe study was conducted on 71 females with BC, along with 70 control females matched in age. Blood samples were collected from all individuals in this study for laboratory investigation and RT-PCR assay for TLR4 and MYD88 gene.

resultsBC group showed a significant increase in tumor markers (CA 15-3 and CEA) compared to control group. Additionally, the expression of TLR4 and MYD88 were significantly increased in BC group compared to controls. The BC surrogate molecular subtypes showed a gradual increase in the expression level of both genes, with significant difference observed with the control group. ROC curve represented a strong discriminating ability for TLR4 and MYD88 in the differentiation BC from control (AUC= 0.966, 0.900, respectively).

conclusionTLR4 and MYD88 were elevated significantly in BC group with strong discriminating power for BC group, estimating their association with BC progression.

Indexed as

Breast NeoplasmsMyeloid Differentiation Factor 88Toll-Like Receptor 4Biomarkers, TumorCase-Control StudiesDisease ProgressionEgyptFemaleGene Expression Regulation, NeoplasticHumansSignal TransductionBiomarkers, TumorMYD88 protein, humanMyeloid Differentiation Factor 88TLR4 protein, humanToll-Like Receptor 4Breast cancerBreast cancer molecular subtypesMYD88Signaling pathwayTLR4

Identifiers

PMID42726166

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.