Evidence map›Paper›PMID 42726145›Full record

ArticlePediatric surgery international2026

Evaluation of atelocollagen implant therapy for a rabbit model of acquired tracheomalacia following tracheostomy.

Juma Obayashi, Junki Koike, Kanji Otsubo, Koji Kojima, Shigeyuki Furuta

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Article in Pediatric surgery international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Juma ObayashiDepartment of Pediatric Surgery, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae, Kawasaki, Kanagawa, 216-8511, Japan. j2obayashi@marianna-u.ac.jp.ORCID https://orcid.org/0000-0003-4269-5376
Junki KoikeDepartment of Diagnostic Pathology, St. Marianna University School of Medicine, Kanagawa, Japan.
Kanji OtsuboDepartment of Chest Surgery, St. Marianna University School of Medicine, Kanagawa, Japan.
Koji KojimaDepartment of Chest Surgery, St. Marianna University School of Medicine, Kanagawa, Japan.
Shigeyuki FurutaDepartment of Pediatric Surgery, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae, Kawasaki, Kanagawa, 216-8511, Japan.

Funding

Japan Society for the Promotion of Science JP24K19344
6 · The paper itself

Abstract

purposeThis study evaluated whether local atelocollagen gel administration prevented airway collapse in a rabbit model of acquired tracheomalacia after tracheostomy.

methodsJapanese white rabbits (≥ 20 weeks) underwent anterior resection of the second-fourth tracheal rings with mucosal preservation. Group A received 1 mL of 3% atelocollagen around the trachea, whereas Group B was untreated. Bronchoscopy was performed preoperatively (Term 1), immediately postoperatively (Term 2), and 3-4 months postoperatively (Term 3). The tracheal lumen area was measured using negative-pressure suction.

resultsSix of seven rabbits in Group A and five of six rabbits in Group B survived. At 30 cmHg, lumen area (%) in Group A was 90.1 ± 19.9 (Term 1), 48.0 ± 40.4 (Term 2), and 69.0 ± 50.3 (Term 3), versus 99.4 ± 7.8, 53.4 ± 20.0, and 15.0 ± 18.8 in Group B. No differences were observed at Terms 1 or 2. At Term 3, lumen area decreased with increasing suction in Group B but was relatively preserved in Group A. Lumen area ≥ 50% at 30 cmHg was observed in 4/6 (66.7%) in Group A and 0/5 (0%) in Group B.

conclusionLocal atelocollagen administration may attenuate airway collapse in tracheomalacia at 3-4 months.

Indexed as

CollagenTracheomalaciaTracheostomyAnimalsBronchoscopyDisease Models, AnimalGelsProstheses and ImplantsRabbitsatelocollagenCollagenGelsAnimal modelAtelocollagenBronchoscopyTracheomalaciaTreatment

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.