Evidence map›Paper›PMID 42726122›Full record

ArticleSurgery today2026

Predictive factors for isolated pulmonary metastasis in pathological T1 colorectal cancer following curative resection with lymph node dissection: a multicenter study.

Kazuhiro Watanabe, Shinobu Ohnuma, Michiaki Unno, Shoichi Saito, Takashi Akiyoshi, Manabu Takamatsu, Kinichi Hotta, Hiroaki Ikematsu, Motohiro Kojima, Yukihide Kanemitsu and 29 more

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Article in Surgery today, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

39 authors.

Kazuhiro WatanabeDepartment of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan. watanabe.kazuhiro@tohoku-mpu.ac.jp.ORCID http://orcid.org/0000-0001-8662-9333
Shinobu OhnumaDepartment of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
Michiaki UnnoDepartment of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
Shoichi SaitoDepartment of Lower Gastrointestinal Medicine, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan.
Takashi AkiyoshiDepartment of Colorectal Surgery, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan.
Manabu TakamatsuDepartment of Pathology, Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan.
Kinichi HottaDivision of Endoscopy, Shizuoka Cancer Center, Sunto City Sunto-gun, Japan.
Hiroaki IkematsuDepartment of Gastroenterology and Endoscopy, National Cancer Center Hospital East, Kashiwa, Japan.
Motohiro KojimaDivision of Pathology, Exploratory Oncology Research & Clinical Trial Center, National Cancer Center, Kashiwa, Japan.
Yukihide KanemitsuDepartment of Colorectal Surgery, National Cancer Center Hospital, Tokyo, Japan.
Yutaka SaitoEndoscopy Division, National Cancer Center Hospital, Tokyo, Japan.
Masayoshi YamadaEndoscopy Division, National Cancer Center Hospital, Tokyo, Japan.
Shigeki SekinePathology and Clinical Laboratory Division, National Cancer Center Hospital, Tokyo, Japan.
Shiro OkaDepartment of Gastroenterology, Hiroshima University Hospital, Hiroshima, Japan.
Shinji TanakaDepartment of Gastroenterology, Hiroshima University Hospital, Hiroshima, Japan.
Shinji NagataDepartment of Gastroenterology, Hiroshima City Asa Citizens Hospital, Hiroshima, Japan.
Yoshiki KajiwaraDepartment of Surgery, National Defense Medical College, Tokorozawa, Japan.
Kazutaka YamadaColoproctology Center, Takano Hospital, Kumamoto, Japan.
Kosei HashimotoDepartment of Gastroenterology, Tochigi Cancer Center, Utsunomiya, Japan.
Soichiro IshiharaDepartment of Surgical Oncology, The University of Tokyo, Tokyo, Japan.
Yusuke SaitohDigestive Disease Center, Asahikawa City Hospital, Asahikawa, Japan.
Kenji MatsudaSecond Department of Surgery, School of Medicine, Wakayama Medical University, Wakayama, Japan.
Kazutomo TogashiDepartment of Coloproctology, Aizu Medical Center, Fukushima Medical University, Aizuwakamatsu, Japan.
Koji KomoriDepartment of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Japan.
Megumi IshiguroHealth Science Research & Development Center, Institute of Science, Tokyo Hospital, Tokyo, Japan.
Yuzuru TamaruDepartment of Endoscopy, NHO Kure Medical Center and Chugoku Cancer Center, Kure, Japan.
Takashi OkuyamaDepartment of Surgery, Dokkyo Medical University Saitama Medical Center, Saitama, Japan.
Shinpei MinamiDepartment of Gastroenterology, School of Medicine, Kurume University, Kurume, Japan.
Kazuhiro SakamotoDepartment of Coloproctological Surgery, Juntendo University Faculty of Medicine, Tokyo, Japan.
Tamotsu SugaiDepartment of Molecular Diagnostic Pathology, School of Medicine, Iwate Medical University, Shiwa, Japan.
Kenji KatsumataDepartment of Gastrointestinal and Pediatric Surgery, Tokyo Medical University, Tokyo, Japan.
Hiro-O MatsushitaDigestive Disease Center, Akita Red Cross Hospital, Akita, Japan.
Hiro-O YamanoDepartment of Gastroenterology and Hepatology, Sapporo Medical University School of Medicine, Sapporo, Japan.
Keisuke NakaiDepartment of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan.
Toshio UraokaDepartment of Gastroenterology and Hepatology, Gunma University Graduate School of Medicine, Maebashi, Japan.
Naohiko AkimotoDepartment of Gastroenterology, Nippon Medical School, Graduate School of Medicine, Tokyo, Japan.
Hirotoshi KobayashiDepartment of Surgery, Tokyo Metropolitan Hiroo Hospital, Tokyo, Japan.
Kenichi SugiharaInstitute of Science, Tokyo, Tokyo, Japan.
Hideki UenoDepartment of Surgery, National Defense Medical College, Tokorozawa, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aimed to clarify the incidence and risk factors for isolated pulmonary metastases following the curative resection of pathological T1 colorectal cancer (pT1 CRC).

methodsWe retrospectively analyzed 3171 patients who underwent curative resection with lymph node dissection for pT1 CRC at 27 Japanese institutions between 2009 and 2016. Potential risk factors were evaluated using Cox proportional hazard regression models.

resultsDuring a median follow-up of 64 months, 21 patients (0.7%) developed isolated pulmonary metastases. The 5-year cumulative incidence was 1.2% for rectal cancer (n = 9/812) and 0.6% for colon cancer (n = 12/2359). An exploratory multivariate analysis identified rectal location and pedunculated (Ip) morphology as potential risk factors. In subgroup analyses, lymphatic invasion was associated with pulmonary metastasis in rectal cancer, whereas the Ip morphology and tumor size ≥ 20 mm were associated with pulmonary metastasis in colon cancer. Patients with rectal cancer with positive lymphatic invasion showed a 5-year cumulative incidence of 2.5% (n = 6/256). In colon cancer, patients with two identified risk factors exhibited a 5-year incidence of 5.1% (n = 5/109 patients).

conclusionsAlthough pulmonary metastases are rare in this surgical pT1 CRC cohort, specific clinicopathological features appear to increase this risk. These findings may help identify candidates for future investigations of risk-adapted surveillance strategies.

Indexed as

Colon cancerpT1Pulmonary metastasisRectal cancerSurgery

Identifiers

PMID42726122

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