ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2026
Correlation between the optical density ratio of subretinal fluid in OCT images and visual outcome in eyes with diabetic MacularEdema.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess the correlation between the optical density ratio (ODR) of subretinal fluid (SRF) on optical coherence tomography (OCT) and the visual response in eyes with diabetic macular edema (DME), and to evaluate whether the ODR of SRF in DME patients with serous retinal detachment can serve as a potential biomarker for predicting treatment response.
methodsA retrospective study was conducted on 101 cases of 120 eyes with diabetic macular edema and serous retinal detachment (SRD) who received intravitreal injection treatment for the first time. Among them, 88 eyes were treated with the anti-VEGF drug Conbercept, and 32 eyes were treated with intravitreal injection of a single Dexamethasone Intravitreal Implant (DEX-I). The subretinal fluid optical density was measured, and ODR was computed via ImageJ software. Eyes were divided into the low ODR group (n = 60) and the high ODR group (n = 60) according to the baseline subretinal fluid ODR value. The therapeutic response to different intravitreal drugs were compared between the two groups, so as to analyzed to assess the correlation between baseline subretinal fluid ODR with visual acuity and conventional OCT indicators in DME patients.
resultsBoth the low ODR group and the high ODR group showed a significant decrease in the SRF height and Central Macular Thickness after treatment (P < 0.0001). The low ODR group showed asubstantial improvement in BCVA after treatment (P < 0.0001), while the high ODR group showed no significant change after treatment (P = 0.482).
conclusionIn DME patients with SRD, patients with a lower baseline subretinal fluid ODR had better visual quality recovery after the anti-VEGF drug or steroid hormone treatment, identifying the optical density in subretinal fluid as a clinically relevant biomarker in diabetic macularedema.
Indexed as
Identifiers
42726113What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.