Evidence map›Paper›PMID 42725884›Full record

ArticleeLife2026

Intersecting experimental evolution and CRISPR screens to identify novel toxin resistance loci.

Michele Marconcini, Steeve Cruchet, Srishti Goswami, Raghuvir Viswanatha, Matthew Butnaru, Joydeep De, Camilla Roselli, Dafni Hadjieconomou, Norbert Perrimon, Stephanie E Mohr and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Michele MarconciniCenter for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.ORCID https://orcid.org/0000-0002-6785-9106
Steeve CruchetCenter for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.
Srishti GoswamiDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, United States.
Raghuvir ViswanathaDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, United States.ORCID https://orcid.org/0000-0002-9457-6953
Matthew ButnaruDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, United States.
Joydeep DeInstitut du Cerveau-Paris Brain Institute, Sorbonne Université, Inserm, CNRS, Paris, France.
Camilla RoselliInstitut du Cerveau-Paris Brain Institute, Sorbonne Université, Inserm, CNRS, Paris, France.
Dafni HadjieconomouInstitut du Cerveau-Paris Brain Institute, Sorbonne Université, Inserm, CNRS, Paris, France.ORCID https://orcid.org/0009-0003-1162-4417
Norbert PerrimonDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, United States.ORCID https://orcid.org/0000-0001-7542-472X
Stephanie E MohrDepartment of Genetics, Blavatnik Institute, Harvard Medical School, Boston, United States.ORCID https://orcid.org/0000-0001-9639-7708
Richard BentonCenter for Integrative Genomics, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Switzerland.ORCID https://orcid.org/0000-0003-4305-8301

Funding

Resource Component: Acquisition, maintenance and distribution of Drosophila stocksP40OD018537 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Annette L. Parks · 2014 to 2026
$13.5M
European Research Council 10.3030/101117267European Research Council 10.3030/833548NIH HHS P40 OD018537Schweizerische Nationalfonds zur Förderung der wissenschaftlichen Forschung 310030_219185Schweizerische Nationalfonds zur Förderung der wissenschaftlichen Forschung 3200-0-239882
6 · The paper itself

Abstract

Understanding toxin resistance in insects is key to appreciating niche adaptations but remains challenging due to its often-polygenic basis. A well-known example is the specialized association of

Indexed as

CaprylatesClustered Regularly Interspaced Short Palindromic RepeatsDrosophilaDrosophila simulansDrug ResistanceAnimalsCRISPR-Cas SystemsDrosophila melanogasterDrosophila ProteinsMorindaCaprylatesDrosophila Proteinsoctanoic acidD. melanogasterD. sechelliaD. simulansevolutionary biologyexperimental evolutiongeneticsgenomicsS2R+ cellsselectiontoxicology

Identifiers

PMID42725884
PMCPMC13568702

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.