Evidence map›Paper›PMID 42725813›Full record

ArticleJournal of cellular and molecular medicine2026

Increased NETosis in Patients With Heart Failure Is Associated With Macrophage Activation Towards a Proinflammatory Phenotype.

Sawa Kostin, Hector A Cabrera-Fuentes, Manfred Richter, Florian Krizanic, Oliver Ritter, William A Boisvert, Klaus T Preissner, Theodoros Kelesidis, Gerasimos Siasos, Nikolaos Pagonas

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular and molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sawa KostinFaculty of Health Sciences Brandenburg, Brandenburg Medical School Theodor Fontane, Neuruppin, Germany.ORCID https://orcid.org/0000-0002-1594-9476
Hector A Cabrera-FuentesDivisión de Estudios de Posgrado e Investigación, Tecnológico Nacional de México/Instituto Tecnológico de Tijuana, Tijuana, Mexico.ORCID https://orcid.org/0000-0002-8502-7098
Manfred RichterDepartment of Cardiac Surgery, Kerckhoff-Clinic, Bad Nauheim, Germany.ORCID https://orcid.org/0000-0002-6239-3503
Florian KrizanicFaculty of Health Sciences Brandenburg, Brandenburg Medical School Theodor Fontane, Neuruppin, Germany.ORCID https://orcid.org/0009-0002-9116-9110
Oliver RitterFaculty of Health Sciences Brandenburg, Brandenburg Medical School Theodor Fontane, Neuruppin, Germany.ORCID https://orcid.org/0000-0003-2069-4364
William A BoisvertCenter for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA.ORCID https://orcid.org/0000-0003-2574-9176
Klaus T PreissnerDepartment of Cardiology, Kerckoff Heart Research Institute, Justus-Liebig-University, Giessen, Germany.
Theodoros KelesidisSouthwestern Medical Center, University of Texas, Dallas, Texas, USA.ORCID https://orcid.org/0000-0002-8463-3811
Gerasimos Siasos3rd Department of Cardiology, 'Sotiria' Chest Disease Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.ORCID https://orcid.org/0000-0001-7601-8870
Nikolaos PagonasFaculty of Health Sciences Brandenburg, Brandenburg Medical School Theodor Fontane, Neuruppin, Germany.ORCID https://orcid.org/0000-0003-3226-8135

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In this study, we tested the hypothesis that there is an interaction between neutrophils (N) undergoing NETosis and the activation of macrophages (Mf) in the myocardium of patients with heart failure (HF). Ventricular biopsies were examined from patients with HF due to dilated (DCM, n = 7), ischemic (ICM, n = 7), or inflammatory (InfCM, n = 7) cardiomyopathy, as well as from 5 control patients. Quantification of CD66b

Indexed as

Extracellular TrapsHeart FailureInflammationMacrophage ActivationMacrophagesAgedAntigens, CDCell Adhesion MoleculesDC-Specific ICAM-3 Grabbing NonintegrinFemaleGPI-Linked ProteinsHumansLectins, C-TypeMaleMannose-Binding LectinsMannose ReceptorAntigens, CDCEACAM8 protein, humanCell Adhesion MoleculesDC-Specific ICAM-3 Grabbing NonintegrinGPI-Linked ProteinsLectins, C-TypeMannose-Binding LectinsMannose ReceptorPeroxidaseReceptors, Cell SurfaceTumor Necrosis Factor-alphaheart failureinflammationmacrophagesNETosisneutrophils

Identifiers

PMID42725813
PMCPMC13564250

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.